Estimating the Malaria Prevention Impact of New Nets: Observational Analyses to Evaluate the Evidence Generated During Piloted New Net Distributions in Rwanda

Condition:   Malaria Interventions:   Other: Standard long-lasting insecticidal net;   Other: Chlorfenapyr insecticide treated net;   Other: Indoor residual spraying Sponsors:   PATH;   Rwanda Biomedical Centre;   University of Rwanda;   Liverpool School of Tropical Medicine Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

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Authors: Nkoy AB, Ndiyo YM, Matoka TT, Odio BM, Kazadi OK, Aloni MN, Collard L, McCulloch M, Ngiyulu RM, Gini JE, Lepira FB, van den Heuvel LP, Levtchenko E, Ekulu PM Abstract In the Democratic Republic of Congo (DRC), acute kidney injury (AKI) contributes to the high rate of child mortality owing to the conjunction of poverty, deficiency of qualified health-care providers in pediatric nephrology, and the lack of pediatric dialysis programs. We aimed to describe the recent experience of the first pediatric acute peritoneal dialysis (PD) program in DRC. This is a retrospective cohort study on epidemiology, clinical ...
Source: Peritoneal Dialysis International - Category: Urology & Nephrology Tags: Perit Dial Int Source Type: research
Plasmodium vivax is the most widespread human malaria parasite outside Africa and is the predominant parasite in the Americas. Increasing reports of P. vivax disease severity, together with the emergence of drug-...
Source: Malaria Journal - Category: Infectious Diseases Authors: Tags: Research Source Type: research
According to the World Health Organization reports, billions of people around the world are at risk for malaria disease and it is important to consider the preventive strategies for protecting the people that ...
Source: Malaria Journal - Category: Infectious Diseases Authors: Tags: Research Source Type: research
ConclusionsThis study of adult African in-patients with falciparum malaria with and without HIV co-infection, neither confirms nor rejects previous studies of malaria qPCR in plasma as an indicator of disease severity in patients with falciparum malaria. There is a need for further and larger studies to clarify if parasitemia as assessed malaria qPCR in plasma could be a surrogate marker of disease severity in falciparum malaria.
Source: Infection - Category: Infectious Diseases Source Type: research
ConclusionsInterventions in Malawi, Peru, and China suggest social innovation increases uptake of diagnostics. The same tools and principles utilized in these cases can be adapted for use in other contexts. Such diagnostic innovations may help improve identification of and linkage to care for many diseases. The approach presents a unique opportunity to better address public health issues and increase accessibility in LMIC health systems.
Source: Infectious Diseases of Poverty - Category: Infectious Diseases Source Type: research
Findings suggest drugs targeting immune cells may help treat deadly disease mainly affecting children.
Source: National Institutes of Health (NIH) News Releases - Category: American Health Source Type: news
[SAnews.gov.za] A hi-tech facility set to develop ground-breaking research towards malaria eradication in South Africa will open at the National Institute for Communicable Diseases, in Johannesburg, on Friday.
Source: AllAfrica News: Malaria - Category: Infectious Diseases Source Type: news
BACKGROUND Cerebral malaria (CM) accounts for nearly 400,000 deaths annually in African children. Current dogma suggests that CM results from infected RBC (iRBC) sequestration in the brain microvasculature and resulting sequelae. Therapies targeting these events have been unsuccessful; findings in experimental models suggest that CD8+ T cells drive disease pathogenesis. However, these data have largely been ignored because corroborating evidence in humans is lacking. This work fills a critical gap in our understanding of CM pathogenesis that is impeding development of therapeutics.METHODS Using multiplex immunohistochemist...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
This study sheds new light on the mechanisms behind blood-brain barrier breakdown in this complicated neurological disease and opens up alternative approaches for treatment.
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
(NIH/National Institute of Neurological Disorders and Stroke) Researchers at the National Institutes of Health found evidence that specific immune cells may play a key role in the devastating effects of cerebral malaria, a severe form of malaria that mainly affects young children. The results, published in the Journal of Clinical Investigation, suggest that drugs targeting T cells may be effective in treating the disease. The study was supported by the NIH Intramural Research Program.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
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