Decoding Bone Marrow Fibrosis in Myelodysplastic Syndrome

The presence of grade 3 BMF is associated with reduced OS independent from IPSS-R; however, BMF grade did not impact response to hypomethylating agent or lenalidomide treatment. TP53 and SETBP1 mutations occurred with greater frequency among patients with severe fibrosis.

Source: Clinical Lymphoma, Myeloma and Leukemia - January 13, 2020 Category: Hematology Authors: Megan Melody, Najla Al Ali, Ling Zhang, Hanadi Ramadan, Eric Padron, David Sallman, Kendra Sweet, Jeffrey Lancet, Alan List, John M. Bennett, Rami Komrokji Tags: Original Study Source Type: research