Molecular profiling for precision cancer therapies

We describe novel molecular characterization strategies beyond tumor DNA sequencing, such as transcriptomics, immunophenotyping, epigenetic profiling, and single-cell analyses. We also review current and potential applications of liquid biopsies to evaluate blood-based biomarkers, such as circulating tumor cells and circulating nucleic acids. Last, lessons learned from the existing limitations of genotype-derived therapies provide insights into ways to expand precision medicine beyond genomics.

http://link.springer.com/10.1186/s13073-019-0703-1

Source: Genome Medicine - January 13, 2020 Category: Genetics & Stem Cells Source Type: research