The cannabinoid ligands SR141716A and AM251 enhance human and mouse islet function via GPR55-independent signalling.

CONCLUSION: These observations may be useful in directing development of peripherally restricted novel therapeutics that are structurally related to SR141716A and AM251, and which potentiate glucose-induced insulin secretion and stimulate β-cell proliferation.
PMID: 31925452 [PubMed - as supplied by publisher]

Source: Cellular and Molecular Life Sciences : CMLS - January 9, 2020 Category: Cytology Authors: Ruz-Maldonado I, Liu B, Atanes P, Pingitore A, Huang GC, Choudhary P, Persaud SJ Tags: Cell Mol Life Sci Source Type: research