Antitumor activity of interleukin-18 on A549 human lung cancer cell line

Conclusion: Using a lentiviral expression vector, IL-18 was expressed stably and efficiently in A549 cells, which showed attenuated proliferation and tumor cell growth, and enhanced tumor cell apoptosis. IL-18 expression also induced the secretion of IFN-γ, while decreasing the production of IL-4, therefore restoring the balance between Th1/Th2 cell subsets. These findings further demonstrated the antitumor activity of IL-18 and might open new therapeutic avenues for the prevention and treatment of lung cancer.

Source: Journal of Cancer Research and Therapeutics - January 12, 2020 Category: Cancer & Oncology Authors: Donglan Xiong Rui Feng Sheng Yang Tingyan Lin Xiangqi Chen Source Type: research