PARP9 enhances infiltration of mononuclear cells in pSS through IFIT1 ‐mediated upregulation of CXCL10

ConclusionThis study is the first to implicate PARP9 as a regulator of infiltration of mononuclear cells in pSS progression and reveal that PARP9 increased CXCL10 expression through upregulating IFIT1 which is mediated by phosphorylation of STAT1. PARP9 might therefore be a novel therapeutic target for pSS.

Source: Arthritis and Rheumatology - December 25, 2019 Category: Rheumatology Authors: Qingqing Tian, Han Zhao, Hanzhi Ling, Li Sun, Chipeng Xiao, Guoyu Yin, Xiaobing Wang, Gan Wu, Chenglin Yang, Mu Chen, Shengwei Jin, Xinyu Yang, Jianguang Wang Tags: FULL LENGTH Source Type: research