Low-dose Perampanel rescues cortical gamma dysregulation associated with parvalbumin interneuron GluA2 upregulation in epileptic Syngap1+/- mice

Loss-of-function SYNGAP1 mutations cause a neurodevelopmental disorder characterized by intellectual disability and epilepsy. SYNGAP1 is a Ras-GTPase-activating protein that underlies the formation and experience-dependent regulation of postsynaptic densities. The mechanisms that contribute to this proposed monogenic cause of intellectual disability and epilepsy remain unresolved.

Source: Biological Psychiatry - January 8, 2020 Category: Psychiatry Authors: Brennan J. Sullivan, Simon Ammanuel, Pavel A. Kipnis, Yoichi Araki, Richard L. Huganir, Shilpa D. Kadam Tags: Archival Report Source Type: research