Preoperative predictors of early relapse/no ‐remission of type‐2 diabetes after metabolic surgery in Chinese patients

The objective of this study is to look for preoperative predictors of early T2DM relapse/no remission in patients with obesity and diabetes who underwent Roux ‐en‐Y gastric bypass (RYGB) or loop duodeno‐jejunal bypass with sleeve gastrectomy (LDJB‐SG). This is a retrospective study of 113 patients who underwent RYGB or LDJB‐SG for T2DM. All T2DM patients with BMI 27.5 to 37.5 kg/m2, having uncontrolled diabetes and T2DM patients with BMI  >  37.5 were included in the study. A multivariate analysis with a logistic regression model was used for analysed factors. Nineteen patients (16.8%) had early relapse and 12 (10.6%) did not have remission. Mean age of patients was significantly more who relapsed/no‐remission (44.9 vs 40.3 years ). On univariate analysis, base line weight (86 vs 96.7 kg) was significantly lower in patients who relapsed/no‐remission. Patients with sustained remission had statistically significant low glycosylated haemoglobin (P <  .030), plasma glucose (120 minutes) (P <  .002) on OGTT, area under curve glucose (P <  .011) values and more C‐peptide (P <  .006) on univariate analysis. Only duration of diabetes (OR 2.78, 95% CI 1.56‐4.97,P <  .001) was found to be independent preoperative factor associated with early relapse/no‐remission. Two years of diabetes duration was the cut‐off point to predict relapse/no‐remission (sensitivity 78.9, specificity 63.4, receiver operating characteristic ...
Source: Clinical Obesity - Category: Eating Disorders & Weight Management Authors: Tags: Original Research Article Source Type: research