449: Longitudinal measurements of proprotein convertase subtilisin kexin 9 (PCSK-9) in patients with and without preeclampsia

Cholesterol (CHOL) synthesis is necessary for healthy fetal and placental maturation and growth in pregnancy, and adverse pregnancy outcomes (APO) have been identified in women with significantly elevated or depressed lipid profiles. Proprotein convertase subtilisin kexin 9 (PCSK-9) enzyme degrades the low density receptor (LDL)-receptor found in hepatic and endothelial tissue, thus increases serum LDL through decreased receptor binding and is a surrogate marker for CHOL metabolism. Elevated PCSK-9 levels are associated with hypercholesterolemia and atherosclerosis but its characteristics during pregnancy are not well established.

Source: American Journal of Obstetrics and Gynecology - December 31, 2019 Category: OBGYN Authors: Angela Shaddeau, Juliet Bishop, Tenisha Wilson, Kristin C. Darwin, Theresa Boyer, Alexia Debrosse, Garima Sharma, Dhananjay Vaidya, Pamela Ouyang, Monica Mukherjee, Sammy Zakaria, Thorsten Leucker, Arthur J. Vaught Tags: Poster Session II Source Type: research