Modular Analysis and Design of Biological Circuits.

Modular Analysis and Design of Biological Circuits.
Curr Opin Biotechnol. 2019 Dec 23;63:41-47
Authors: Grunberg TW, Del Vecchio D
Abstract
Modularity has been the subject of intense investigation in systems biology for more than two decades. Whether modularity holds in biological networks is a question that has attracted renewed attention in recent years with the advent of synthetic biology, mostly as a convenient property to perform bottom-up design of complex systems. A number of studies have appeared, which fundamentally challenge modularity as a property of engineered biological circuits. Here, we summarize some of these studies and potential engineering solutions that have been proposed to enable modular composition of biological circuits.
PMID: 31877425 [PubMed - as supplied by publisher]

Source: Current Opinion in Biotechnology - December 22, 2019 Category: Biotechnology Authors: Grunberg TW, Del Vecchio D Tags: Curr Opin Biotechnol Source Type: research