Synthesis, characterization and albumin binding capabilities of quinizarin containing ternary cobalt(III) complexes.

Synthesis, characterization and albumin binding capabilities of quinizarin containing ternary cobalt(III) complexes.
J Inorg Biochem. 2019 Dec 17;204:110963
Authors: Kozsup M, Dömötör O, Nagy S, Farkas E, Enyedy ÉA, Buglyó P
Abstract
Four Co(III) ternary complexes with the composition of [(Co(4 N))2(quin)](ClO4)4 or [(Co(4 N))2(quinS)](ClO4)3, where 4 N = tris(2-aminoethyl)amine (tren) or tris(2-pyridylmethyl)amine (tpa), quinH2 = quinizarin (1,4-dihydroxy-9,10-anthraquinone), quinSH3 = quinizarin-2-sulfonic acid (1,4-dihydroxy-9,10-anthraquinone-2-sulfonic acid), were synthesized, characterized and their human serum albumin (HSA) binding capabilities were also tested. The complexes can be considered as likely chaperons of quinizarins which are structural models for anthracycline-based anticancer drugs like doxorubicin. All the Co(III) complexes are dinuclear and were isolated as mixture of isomers. Comparison of the cyclic voltammograms of the free ligands and the appropriate Co(III) complexes revealed that the new signals belonging to reversible processes in the range -400-0 mV (vs. Ag/AgCl) for the complexes can be attributed to the reversible reduction of the Co(III) centre. These potentials are in the range of typical (O,O) chelated Co(III) ternary complexes bearing 4 N donor ligands and follow the order being more positive for the tpa containing complexes. Presence of the sulfonate group in the quinizarin result...

Source: Journal of Inorganic Biochemistry - December 16, 2019 Category: Biochemistry Authors: Kozsup M, Dömötör O, Nagy S, Farkas E, Enyedy ÉA, Buglyó P Tags: J Inorg Biochem Source Type: research