Rhabdoid morphology in gastrointestinal stromal tumours (GISTs) is associated with PDGFRA mutations but does not imply an aggressive behaviour

ConclusionsRhabdoid gastric GISTs are associated with epithelioid morphology and PDGFRA mutations. They harbour CGH aberrations typical of ordinary GISTs in both tumour components. Presence of additional genetic alterations in the rhabdoid areas indicates a genetic evolution from the epithelioid components and possible genetic and biologic progression. Based on our series and previous reports, rhabdoid morphology in GISTs presumably doesn't imply aggressiveness.This article is protected by copyright. All rights reserved.

http://onlinelibrary.wiley.com/resolve/doi?DOI=10.1111%2Fhis.12265

Source: Histopathology - August 27, 2013 Category: Pathology Authors: Inga‐Marie Schaefer, Philipp Ströbel, Silke Cameron, Alexander Beham, Claudia Otto, Hans‐Ulrich Schildhaus, Abbas Agaimy Tags: Original Article Source Type: research