Development of Quality Measures for Acute Pancreatitis: A  Model for Hospital-Based Measures in Gastroenterology

Acute pancreatitis is one of the most common causes for hospital admissions among gastrointestinal (GI) disorders in the United States, leading to approximately 280,000 patient admissions each year.1 During much of the past 2 decades, the incidence of acute pancreatitis has been rising, perhaps driven by an increased incidence of gallstone disease that may be associated with the obesity epidemic.2,3 Acute pancreatitis is associated with significant morbidity, especially when severe, and with mortality rates greater than 1%.
Source: Clinical Gastroenterology and Hepatology - Category: Gastroenterology Authors: Tags: Practice Management: The Road Ahead Source Type: research

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Authors: Caixàs A, Villaró M, Arraiza C, Montalvá JC, Lecube A, Fernández-García JM, Corio R, Bellido D, Llisterri JL, Tinahones FJ Abstract The high prevalence of obesity in our environment, a chronic disease of complex management and responsible for multiple comorbidities, requires the implementation of coordination strategies in clinical care between primary care and specialist hospital units. In a cross-sectional care model, primary care physicians guide all therapeutic management related to obesity. Together with them, specialists in endocrinology and nutrition and other heal...
Source: Medicina Clinica - Category: General Medicine Tags: Med Clin (Barc) Source Type: research
Publication date: Available online 22 February 2020Source: Computational and Structural Biotechnology JournalAuthor(s): Abhijit Dasgupta, Gautam K. Bandyopadhyay, Indrani Ray, Keya Bandyopadhyay, Nirmalya Chowdhury, Rajat K. De, Sushil K. MahataAbstractObesity is characterized by a state of chronic, unresolved inflammation in insulin-targeted tissues. Obesity-induced inflammation causes accumulation of proinflammatory macrophages in adipose tissue and liver. Proinflammatory cytokines released from tissue macrophages inhibits insulin sensitivity. Obesity also leads to inflammation-induced endoplasmic reticulum (ER) stress a...
Source: Computational and Structural Biotechnology Journal - Category: Biotechnology Source Type: research
In this study, fluorescence emission spectroscopy and mass spectrometry (MALDI-TOF) were employed to define the putative interaction sites and their accessibility for the biologically important metals of Irving William Series.Key findingsSeveral hotspot residues in the ZAG scaffold involved in these interactions were mapped and their binding affinity score for each metal has been determined. Their binding abilities of these sites and aggregation propensities of ZAG were monitored by fluorescence emission spectroscopy.SignificanceThe prediction of such binding affinity with metals on the active sites and its impact on the c...
Source: Life Sciences - Category: Biology Source Type: research
Publication date: Available online 21 February 2020Source: PeptidesAuthor(s): Qiaoling Wang, Kathrin I. Liszt, Inge DepoortereAbstractTaste perception on the tongue is essential to help us to identify nutritious or potential toxic food substances. Emerging evidence has demonstrated the expression and function of bitter taste receptors (TAS2Rs) in a wide range of extra-oral tissues. In particular, TAS2Rs in gastrointestinal enteroendocrine cells control the secretion of appetite regulating gut hormones and influence hunger and food intake. Furthermore, these effects may be reinforced by the presence of TAS2Rs on intestinal ...
Source: Peptides - Category: Biochemistry Source Type: research
CONCLUSIONS: Given increasing rates of opioid addiction and death, viable solutions are universally needed. Successful intervention measures should be widely shared between military, veteran, and civilian healthcare and public health communities. Increased collaboration between these groups could inculcate successful programs to prevent and decrease opioid use. Results received from recent military and veterans' programs for prescription and electronic medical record (EMR) monitoring and data sharing may also prove useful for civilian healthcare providers and hospital systems. Future evaluations from ongoing federally fund...
Source: Military Medicine - Category: International Medicine & Public Health Tags: Mil Med Source Type: research
Authors: Shiroma PR, Velasquez T, Usset TJ, Wilhelm JH, Thuras P, Baltutis E Abstract INTRODUCTION: Obesity is prevalent among users of Veteran's Health Administration services, where it is comorbid with depression, post-traumatic stress disorder, type 2 diabetes, cardiovascular disease, colon, and breast cancer. Among obese subjects, severe obesity represents a subpopulation with the highest risk of depression. We investigate the antidepressant effect of a local VA weight management program (Managing Overweight Veterans Everywhere - MOVE) among depressed veterans with severe obesity. MATERIAL AND METHODS: In a...
Source: Military Medicine - Category: International Medicine & Public Health Tags: Mil Med Source Type: research
Authors: Gluszewska A, Gryglewska B, Rewiuk K, Zarzycki B, Dzieza-Grudnik A, Kwater A, Major P, Budzynski A, Gasowski J, Grodzicki T Abstract Subclinical arterial damage connected with endothelial dysfunction is a common denominator of cardiovascular complications in a variety of metabolic diseases, including obesity. The aims of the study was to assess functional vascular changes measured by flow-mediated dilatation (FMD) and nitroglycerin-mediated dilation (NMD) of brachial artery, and to measure vascular structural alterations estimated by carotid intima-media complex thickness (IMT) in short- (10 days) and medi...
Source: Journal of Physiology and Pharmacology - Category: Drugs & Pharmacology Tags: J Physiol Pharmacol Source Type: research
Authors: Yu JH, Lim JW, Kim H Abstract Pancreatitis is a disease for which there are numerous etiologies but no effective treatments. Although the expression of the pancreatitis-associated protein-1 (PAP-1) serves as a marker for the disease, its biological function is unknown. The present study was carried out to determine if PAP-1 performs a protective role against oxidative stress-induced pancreatic cell death. For this purpose, we used cerulein-stimulated pancreatic acinar AR42J cells as an experimental model of acute pancreatitis. First, we demonstrated that PAP-1 gene expression is increased by cerulein in a ...
Source: Journal of Physiology and Pharmacology - Category: Drugs & Pharmacology Tags: J Physiol Pharmacol Source Type: research
Authors: Buzcu H, Ozbeyli D, Yuksel M, Cilingir Kaya OT, Kasimay Cakir O Abstract Nesfatin-1, a recently discovered peptide, was shown to have anti-inflammatory effects. Acute pancreatitis (AP) is a life-threatening condition caused by various reasons. Although the etiology of AP is well-known, its pathogenesis is not clear. The aim of this study is to investigate the possible anti-inflammatory role of nesfatin-1 and its probable protective underlying mechanisms in an acute pancreatitis model. Caerulein was applied intraperitoneally to induce acute pancreatitis in Sprague-Dawley female rats. Nesfatin-1 was administ...
Source: Journal of Physiology and Pharmacology - Category: Drugs & Pharmacology Tags: J Physiol Pharmacol Source Type: research
This past October, President Trump issued a proclamation that would bar immigrants in certain visa categories from entering the United States unless they purchase specified forms of health coverage or have the resources necessary to pay “reasonably foreseeable” medical costs. The stated motive is to reduce the costs of uncompensated care, or expenses incurred by hospitals and other providers when they deliver services to people without health coverage or the ability to pay.        
Source: The Commonwealth Fund: Blog - Category: International Medicine & Public Health Authors: Source Type: blogs
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