13 Assessment of interplay effect using a programmable motion platform

Introduction. Radiation Therapy of the thoracic region is confronted to the respiratory movement. When fluency is modulated (VMAT) and high doses (SBRT) are used, an Interplay Effect (IE) can appear. This is an unfortunate combination of the respiratory and leaf movements of the Multi-leafs Collimator that could lead to under-dosing of the target or over-dosing of risk organs. In the literature, the IE has been studied and depends on a large number of parameters: dose rate, dose per fraction, number of fractions, period and amplitude of breathing, beam energy, complexity of modulation, etc.

Source: Physica Medica: European Journal of Medical Physics - November 30, 2019 Category: General Medicine Authors: I. Medjahed, J. Leste, F.X. Arnaud, L. Vieillevigne, L. Simon Source Type: research