Impact of Low Flow on the Outcome of High-Risk Patients Undergoing Transcatheter Aortic Valve Replacement

This study sought to assess the impact of baseline left ventricular (LV) outflow, LV ejection fraction (LVEF), and transvalvular gradient on outcomes following transcatheter aortic valve replacement (TAVR) in patients with severe aortic stenosis (AS).Background: Low flow (i.e., reduced stroke volume index [SVi]) can occur with both reduced and preserved LVEF. Low flow is often associated with low gradient despite severe stenosis and with worse outcomes following surgical aortic valve replacement. However, there are few data about the impact of low flow on outcomes following TAVR.Methods: We retrospectively analyzed the clinical, Doppler-echocardiographic, and outcome data prospectively collected in 639 patients who underwent TAVR for symptomatic severe AS in 2 Canadian centers.Results: In this cohort, 334 (52.3%) patients had a low flow (SVi 

Source: Journal of the American College of Cardiology - June 14, 2013 Category: Cardiology Authors: Florent Le Ven, Mélanie Freeman, John Webb, Marie-Annick Clavel, Miriam Wheeler, Éric Dumont, Chris Thompson, Robert De Larochellière, Robert Moss, Daniel Doyle, Henrique B. Ribeiro, Marina Urena, Luis Nombela-Franco, Josep Rodés-Cabau, Philippe Pibar Tags: Transcatheter Aortic Valve Replacement Source Type: research