A proposal for the interpretation of the serum IGF-I concentration as part of laboratory screening in children with growth failure

A proposal for the interpretation of the serum IGF-I concentration as part of laboratory screening in children with growth failure J Clin Res Pediatr Endocrinol. 2019 Dec 17;: Authors: Wit JM, Bidlingmaier M, de Bruin C, Oostdijk W Abstract The serum IGF-I concentration is commonly used as a screening tool for growth hormone deficiency (GHD), but there is no consensus on the cut-off limit of IGF-I standard deviation score (SDS) to perform GH stimulation tests for confirmation or exclusion of GHD. We argue that the cut-off limit is dependent on the clinical pre-test likelihood of GHD and propose a diagnostic strategy in which the cut-off limit varies between none to -2 SDS. PMID: 31842524 [PubMed - as supplied by publisher]
Source: JCRPE Journal of Clinical Research in Pediatric Endocrinology - Category: Endocrinology Tags: J Clin Res Pediatr Endocrinol Source Type: research