Obese men have more advanced and more aggressive prostate cancer at time of surgery than non-obese men after adjusting for screening PSA level and age: results from two independent nested case–control studies

Obese men have more advanced and more aggressive prostate cancer at time of surgery than non-obese men after adjusting for screening PSA level and age: results from two independent nested case–control studies Prostate Cancer and Prostatic Diseases advance online publication, August 20 2013. doi:10.1038/pcan.2013.27 Authors: A S Parker, D D Thiel, E Bergstralh, R E Carlson, L J Rangel, R W Joseph, N Diehl &R J Karnes
Source: Prostate Cancer and Prostatic Diseases - Category: Urology & Nephrology Authors: Tags: obesity PSA aggressiveness screening Source Type: research

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ConclusionTRT can reliably improve global sexual function in men with hypogonadism in the short term. Long ‐term clinical benefits, and safety of TRT in functional hypogonadism, remain to be fully documented. Clinicians should therefore explicitly discuss the uncertainties and benefits of TRT and engage them in shared management decision‐making.
Source: Andrology - Category: Urology & Nephrology Authors: Tags: REVIEW ARTICLE Source Type: research
Prostate Cancer and Prostatic Diseases, Published online: 06 February 2020; doi:10.1038/s41391-020-0208-4Obesity-associated inflammation induces androgenic to estrogenic switch in the prostate gland
Source: Prostate Cancer and Prostatic Diseases - Category: Urology & Nephrology Authors: Source Type: research
Breakthrough treatments for lung cancer and melanoma have driven down cancer mortality overall — and from 2016 to 2017 spurred the largest-ever decline.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Cancer Smoking and Tobacco Lung Cancer Colon and Colorectal Cancer Breast Cancer Cervical Cancer Prostate Cancer Obesity American Cancer Society your-feed-healthcare Source Type: news
Authors: Wilson KM, Mucci LA Abstract A variety of diet and lifestyle factors have been studied with respect to prostate cancer risk in large, prospective cohort studies. In spite of this work, and in contrast to other common cancers, few modifiable risk factors have been firmly established as playing a role in prostate cancer. There are several possible explanations for the lack of well-established risk factors. First, prostate cancer has among the highest heritability of all common cancers; second, early life exposures may play an important role in risk, rather than mid- and later-life exposures assessed in most ...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
AbstractPelvic lymph node dissection (pLND) is considered the most reliable method for the detection of lymph node metastases in prostate cancer. Current clinical guidelines recommend performing pLND in intermediate- and high-risk patients that are defined using different clinical nomograms and different cut-off values. Although the detection of lymph node metastatic disease can identify patients who could benefit from adjuvant therapies and potentially improve prostate cancer-related survival outcomes, so far there has been no level 1 evidence to support this survival benefit. Available retrospective data that suggest onc...
Source: Journal of Robotic Surgery - Category: Surgery Source Type: research
The objective was to evaluate the health-related lifestyles and cancer-preventive behaviors of medical and nursing students and FM residents in relation to the European Code Against Cancer (ECAC). This was a descriptive, cross-sectional study performed in Spain. Medical and nursing students and FM residents completed a self-administered questionnaire focused on health-related habits and clinical behaviors related to the ECAC. A total of 740 participants completed the questionnaire. About 12.2% (95% CI [9.8 –14.5]) were smokers, and 77.3% (95% CI [74.3–80.3]) sporadically consumed alcohol; 34.2% (95% CI [30.8&nd...
Source: Journal of Cancer Education - Category: Cancer & Oncology Source Type: research
ConclusionNomograms with excellent discriminative ability were developed and validated. These nomograms can be used to select the optimal biopsy strategy for individual patients in the future.
Source: Annals of Surgical Oncology - Category: Cancer & Oncology Source Type: research
This study raises serious concerns about whether we’ve been careful enough about the safety of this chemical,” said Patricia Hunt, a professor of molecular bioscience at Washington State, and a corresponding author of the paper, in a statement. Despite how huge the difference, the results are not getting much evident pushback from other researchers in the field. “It honestly blew my mind—not because I don’t believe it, but because it appears to be true,” says Lori Hoepner, assistant professor of environmental and occupational health sciences at SUNY Downstate School of Public Health. &ld...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized bisphenol a BPA endocrine disruptor Environment Environmental Health Source Type: news
Preclinical studies have suggested the antitumorigenic properties of metformin on prostate cancer; results from epidemiological studies remain contradictory. We aim to investigate the evidence of metformin and the risk of prostate cancer. PubMed, Embase, Cochrane Library, and Web of Science databases were searched for eligible studies. Meta-analyses were carried out using the most fully adjusted hazard ratios and the corresponding 95% confidence intervals. Eighteen cohort studies and six case–control studies representing 2 009 504 male patients with type 2 diabetes mellitus were identified. The pooled HR of prostate ...
Source: European Journal of Cancer Prevention - Category: Cancer & Oncology Tags: Prostate Cancer Source Type: research
Abstract With the onset of a metabolic syndrome epidemic and the increasing life expectancy, erectile dysfunction (ED) has become a more common condition. As incidence and prevalence increase, the medical field is focused on providing more appropriate therapies. It is common knowledge that ED is a chronic condition that is also associated with a myriad of other disorders. Conditions such as aging, diabetes mellitus, hypertension, obesity, prostatic hypertrophy, and prostate cancer, among others, have a direct implication on the onset and progression of ED. Characterization and recognition of risk factors may help ...
Source: Asian Journal of Andrology - Category: Urology & Nephrology Authors: Tags: Asian J Androl Source Type: research
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