Malignant priapismus induced by adenocarcinoma of the prostate

In this study, we present a case of malignant priapism due to penile metastasis of adenocarcinoma of the prostate, an extremely rare clinical entity and a more uncommon site of metastasis.
Source: Urology Case Reports - Category: Urology & Nephrology Source Type: research

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ConclusionsTo support decision making following progression to immunotherapy-based treatment in patients with advanced wild-type lung adenocarcinoma, a consensus document has been developed.
Source: Clinical and Translational Oncology - Category: Cancer & Oncology Source Type: research
Conclusions: This study offers insights for future research of CSF miRNAs as robust tools for diagnosing and monitoring LM. It also reveals a novel pathway for exploration of underlying mechanisms of LM.
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Authors: Kuo PH, Teng YH, Cin AL, Han W, Huang PW, Wang LH, Chou YT, Yang JL, Tseng YL, Kao M, Chang MD Abstract Nanoparticles (NPs), such as liposomes, effectively evade the severe toxicity of unexpected accumulation and passively shuttle drugs into tumor tissues by enhanced permeability and retention. In the case of non-small cell lung cancer and pancreatic ductal adenocarcinoma, cancer-associated fibroblasts promote the aggregation of a gel-like extracellular matrix that forms a physical barrier in the desmoplastic stroma of the tumor. These stroma are composed of protein networks and glycosaminoglycans (GAGs) t...
Source: Drug Delivery - Category: Drugs & Pharmacology Tags: Drug Deliv Source Type: research
Authors: Roşu GA, Furău GO, Ionescu CA, Dimitriu MCT, Neacşu A, Ioan RG, Călin FD, Matei A, Bănacu M, Popescu I, Gheorghiu D, Neacşu I, Bacalbaşa N, Furău CG Abstract Epithelial ovarian carcinoma makes up 90-95% of all ovarian malignancies, taking into account also low-malignant-potential tumors. The Krukenberg tumor is a rare metastatic adenocarcinoma (ADK) in the ovary, representing 1-2% of ovarian tumors. Multiple primary malignant neoplasms may exist when more than one cancerous tumor is diagnosed in the same or a different organ. The incidence of multiple primary cancers among malignancies is between 2...
Source: Romanian Journal of Morphology and Embryology - Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research
We report a rare case of a 47-year-old male patient who presented to the Emergency Unit complaining about a two weeks-long-persistent pain in the upper abdomen and biliary vomiting. The medical history included alcohol abuse. Several days prior to the onset of these symptoms, the patient has noticed the occurrence of a nodular inflammatory lesion of 5∕3 cm on the right calf (this makes the case even rarer). Based on clinical aspect and high levels of pancreatic enzymes, acute pancreatitis was diagnosed. Contrast-enhanced abdominal computed tomography (CT) revealed a cystic pancreatic mass and dilated intrahepatic biliary...
Source: Romanian Journal of Morphology and Embryology - Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research
We report a large-cell adenocarcinoma of the lung in a tobacco smoker with classical superior vena cava syndrome and digital clubbing. Computed tomography and nuclear magnetic resonance revealed the involvement of the vena cava and metastases in the left adrenal gland and central nervous system. Biopsy samples of the mass yielded the diagnosis. The patient underwent a schedule of palliative chemotherapy and brain radiotherapy. PMID: 32239113 [PubMed - in process]
Source: Romanian Journal of Morphology and Embryology - Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research
AbstractBackgroundSquamous cell/adenosquamous carcinoma (SC/ASC) is a rarely identified form of gallbladder cancer with poorly understood clinical features. As such, there is an urgent need to identify novel prognostic biomarkers for such gallbladder SC/ASC cases, and for gallbladder adenocarcinomas (ACs).MethodsThe levels of ACO2 and ANPEP proteins were assessed via an EnVision-based immunohistochemical approach using 46 SC/ASC and 80 AC patient samples.ResultsThere was a marked reduction in levels of ACO2 and ANPEP in gallbladder AC relative to normal adjacent tissue or benign gallbladder lesions. The was a significant c...
Source: International Journal of Clinical Oncology - Category: Cancer & Oncology Source Type: research
ALK (Anaplastic lymphoma kinase) rearrangement is the second most common targetable oncogene-dirven gene in NSCLC. It is identified in approximately 3 –7% of NSCLC patients [1], and is highly sensitive to ALK tyrosine kinase inhibitors (TKIs) such as crizotinib, alectinib, ceritinib, brigatinib [2]. EML4-ALK rearrangement was firstly identified by Soda et al. in 2007 [3]. With the development of NGS, more and more novel ALK fusion partners have been identified, such as KIF5B, STRN, KLC1, TPR, HIP1, DCTN1, CMTR1, GCC2, SEC31A and so on.
Source: Lung Cancer - Category: Cancer & Oncology Authors: Source Type: research
Publication date: Available online 3 April 2020Source: Urology Case ReportsAuthor(s): Che-Hsueh Yang, Chin-Heng Lu, Li-Hua Huang, Yen-Chuan Ou, Chao-Yu Hsu, Min-Che Tung
Source: Urology Case Reports - Category: Urology & Nephrology Source Type: research
ConclusionPVR can potentially serve as a prognostic predictor and biomarker for NSCLC and cancer anti-CTLA4 immunotherapy response.
Source: Journal of Cancer Research and Clinical Oncology - Category: Cancer & Oncology Source Type: research
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