Noncontrast Magnetic Resonance Lymphangiography in a Rare Case of Everolimus-Related Lymphedema
We report the case of a 58-year-old man with a history of end-stage renal disease of unknown etiology who had undergone right renal transplantation 11 years before. After the transplant, the patient soon developed bilateral progressive swelling involving feet and legs. The symptoms of the left limb improved markedly after discontinuing everolimus. This condition has been classified as everolimus-induced lymphedema. The patient was referred to our department for the execution of a noncontrast magnetic resonance lymphangiography, that is, a noninvasive magnetic resonance imaging technique that has recently proposed for the study of lymphedema. Noncontrast magnetic resonance lymphangiography showed asymmetry between the lower extremities with signs of advanced lymphedema located in the right lower limb and dilated peripheral lymphatic vessels. Drug withdrawal is currently the only effective solution for treating this type of secondary lymphedema; however, with the prolonged use of the drug, lymphedema tends to persist even after mTOR inhibitor suspension, with only partial clinical improvement, as in this case. This case report describes the imaging characteristics of such condition at noncontrast magnetic resonance lymphangiography and discusses the rare adverse effects of everolimus. Immediate suspension of the drug is the only effective strategy to avoid the persistence of this disorder.
Conditions: Breast Cancer; Mastectomy; Lymphedema; Pain, Shoulder; Mobility Limitation Interventions: Other: Myofascial Massage; Other: Light Touch Sponsor: MetroHealth Medical Center Not yet recruiting
Lymphatic Research and Biology, Ahead of Print.
CONCLUSIONS: Our analysis identified clinical and scintigraphic predictors of primary lymphedema-volume reduction for patients with unilateral disease. Lymphoscintigraphy helps confirm lymphedema and predict volume reduction. Further study is required to confirm these observations. PMID: 31944248 [PubMed - as supplied by publisher]
ConclusionsThe predictive efficiency and accuracy of the scoring system were acceptable, and the system could be used to predict and screen groups at high risk for breast cancer-related lymphedema.
Lymphedema is a public health problem in countries with lymphatic filariasis (LF) including Mali. We studied the epidemiology and clinical presentation of lymphedema in three previously LF-endemic health distr...
Conditions: Breast Neoplasms; Radiotherapy; Lymphedema Interventions: Radiation: Locoregional radiation treatment - Conventional fractionation; Radiation: Locoregional radiation treatment - Hypofractionation Sponsor: Ontario Clinical Oncology Group (OCOG) Not yet recruiting
Some causes of swollen legs and ankles are relatively harmless, while others can be more serious. Discover the different causes and their associated treatments.
Journal of Wound Care,Volume 29, Issue 1, Page 28-35, January 2020.
This study aimed to identify subgroups of breast cancer survivors with the SC of pain, fatigue, and psychological distress, and to examine sociodemographic and clinical characteristics associated with this SC.MethodsData were obtained from a nationwide survey of breast cancer survivors (N = 834). Exhaustive enumeration of possible combination of the three binary variables (pain, fatigue, psychological distress) was conducted. They were identified using the recommended threshold for the Hospital Anxiety and Depression Scale, the Fatigue Questionnaire, and a score of one or more o n a numeric rating scale for p...
Condition: Lymphedema of Limb Intervention: Device: Monterey Pneumatic Compression Device Sponsor: ResMed Recruiting