The challenge of antimicrobial prescribing for hospital-acquired pneumonia

Publication date: Available online 12 December 2019Source: Journal of Hospital InfectionAuthor(s): D.G. Wootton, S.J. Aston, T.W. Felton
Source: Journal of Hospital Infection - Category: Infectious Diseases Source Type: research

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Authors: Saxena P, Muthu V, Dhooria S, Sehgal IS, Prasad KT, Agarwal R Abstract Methotrexate monotherapy is a common management strategy in rheumatoid arthritis (RA). Treatment with immunosuppression can lead to opportunistic infections such as Pneumocystis jirovecii pneumonia (PJP). The treatment options for PJP include cotrimoxazole, clindamycin-primaquine and dapsone. Though these drugs are generally well tolerated, they can result in potentially severe adverse effects. Sometimes several undesired events may occur in a single patient, reminding us of Murphy's law. Herein, we report a case which exemplifies this ...
Source: New Zealand Medical Journal - Category: General Medicine Tags: N Z Med J Source Type: research
Conclusion Patients with SM bacteremia who have hematologic malignancy, thrombocytopenia, and a history of using quinolone within the past 30 days should be treated with deliberation. PMID: 31941869 [PubMed - in process]
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
We examined the effects of nutritional treatment on the prevention of pneumonia. Patients and Methods We retrospectively examined the effects of nutritional treatment on the prevention of pneumonia by analyzing the records of bedridden patients (n=68; mean age: 68.0 years) who stayed in a hospital for 2 years or longer. Results Among the analyzed patients, pneumonia developed in 52 (76%) patients, and the mean frequency of pneumonia was 1.6 times per year during the first year of stay. In a multivariate analysis, the serum albumin level at admission in the pneumonia group was lower than that in the non-pneumonia group. The...
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
Chinese health authorities say a second person has died from a new coronavirus that has caused an outbreak of pneumonia in central China
Source: ABC News: Health - Category: Consumer Health News Tags: Health Source Type: news
A second person has died from pneumonia in the central Chinese city of Wuhan following an outbreak believed to be caused by a new coronavirus strain, local health authorities said.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
Among critically ill patients in the intensive care unit (ICU), complications are frequent, including stress ulcers in the upper gastrointestinal tract. To help prevent the development of ulcers, antagonism of gastric acid (with antacids historically) or inhibition of the production of acid (with histamine-2 receptor blockers more recently) were implemented as part of routine critical care. The introduction of proton pump inhibitors, with data demonstrating improved ulcer prevention and recovery compared with histamine-2 receptor blockers in non –critically ill patients, led many physicians who provide care for criti...
Source: JAMA - Journal of the American Medical Association - Category: General Medicine Source Type: research
This study is registered with (NCT02108964); enrolment to phase 1 is complete and the study is ongoing.FindingsBy Aug 31, 2017, 180 patients (116 [64%] women; median age 60 years (52–69); 116 [64%] with ECOG performance status 1) received nazartinib across seven dose levels: 75 mg (n=17), 100 mg (n=38), 150 mg (n=73), 200 mg (n=8), 225 mg (n=28), 300 mg (n=5), and 350 mg (n=11). Seven dose-limiting toxicities were observed in six (3%) patients who received 150 mg, 225 mg, or 350 mg nazartinib once daily. Although the maximum tolerated dose was not met, the recommended phase 2 dose was declared as 1...
Source: The Lancet Respiratory Medicine - Category: Respiratory Medicine Source Type: research
New diagnostic tests for the etiology of childhood pneumonia are needed. We evaluated the antibody-in-lymphocyte supernatant (ALS) assay to detect immunoglobulin (Ig) G secretion from ex vivo peripheral blood mononuclear cell (PBMC) culture, as a potential diagnostic test for pneumococcal pneumonia. We enrolled 348 children with pneumonia admitted to Patan Hospital, Kathmandu, Nepal between December 2015 and September 2016. PBMCs sampled from participants were incubated for 48 h before harvesting of cell culture supernatant (ALS). We used a fluorescence-based multiplexed immunoassay to measure the concentration of IgG in A...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
ConclusionsSupplementation of mouse diets with Omega-3 fatty acids improved survival, bacterial invasion in the blood and lungs as well as decreased overall lung tissue inflammation and cell death when compared to the Omega-6 supplemented diets. Translation of these findings in humans may improve outcomes of patients at risk for pneumonia.
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
THURSDAY, Jan. 16, 2020 -- Japan has reported its first case of a new coronavirus that has caused an outbreak in China. A Chinese man in his 30s tested positive for the pneumonia-like coronavirus, Japan's Health Ministry said Thursday, The New York...
Source: - Pharma News - Category: Pharmaceuticals Source Type: news
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