Emerging PD-1 and PD-1L inhibitors-associated myopathy with a characteristic histopathological pattern

ConclusionA characteristic clinic-pathological pattern, including a myasthenia gravis-like syndrome plus myositis was found in patients receiving PD-1 and PD-1 L inhibitors. A large component of macrophages resembling granulomas seems to be the pathological hallmark of the syndrome. Further information is required to understand the wide spectrum of immune-related adverse events involving the muscle during or after treatment with anti-PD-1 inhibitors, but the pathological picture seems to be characteristic.
Source: Autoimmunity Reviews - Category: Allergy & Immunology Source Type: research