Postoperative Heme Oxygenase Induction and Carbon Monoxide Production as a Novel Method to Assess Hepatic Regeneration and Predict Hepatic Related Morbidity After Partial Hepatectomy

Condition:   Liver Cancer Interventions:   Procedure: CO Testing Pre/Post Hepatic Resection;   Diagnostic Test: ABG Testing Pre/Post Hepatic Resection;   Diagnostic Test: CT Evaluations Sponsor:   University of Maryland, Baltimore Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

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ConclusionsThe PMI was significantly associated with the survival of lung SCC patients, but not of lung ADC patients, suggesting the presence of a previously unidentified relationship between skeletal muscle and lung SCC progression.
Source: International Journal of Clinical Oncology - Category: Cancer & Oncology Source Type: research
This study aims to evaluate the impact of diffusing capacity of the lung for carbon monoxide (DLco) before and after neoadjuvant concurrent chemoradiotherapy (CCRT) on postoperative pulmonary complication (PPC...
Source: Respiratory Research - Category: Respiratory Medicine Authors: Tags: Research Source Type: research
This study aims to evaluate the impact of diffusing capacity of the lung for carbon monoxide (DLco) before and after neoadjuvant concurrent chemoradiotherapy (CCRT) on postoperative pulmonary complication (PPC) among stage IIIA/N2 non-small-cell lung cancer (NSCLC) patients. METHODS: We retrospectively studied 324 patients with stage IIIA/N2 NSCLC between 2009 and 2016. Patients were classified into 4 groups according to DLco before and after neoadjuvant CCRT; normal-to-normal (NN), normal-to-low (NL), low-to-low (LL), and low-to-very low (LVL). Low DLco and very low DLco were defined as DLco
Source: Respiratory Care - Category: Respiratory Medicine Authors: Tags: Respir Res Source Type: research
Publication date: Available online 27 December 2019Source: The Annals of Thoracic SurgeryAuthor(s): Manato Ohsawa, Yasuhiro Tsutani, Makoto Fujiwara, Takahiro Mimae, Yoshihiro Miyata, Morihito OkadaAbstractBackgroundInterstitial pneumonia (IP) is linked to lung cancer, and treatment can cause acute exacerbation. We aimed to identify predictors of severe postoperative complications in patients with lung cancer and IP.MethodsBetween April 2007 and April 2017, 199 patients were diagnosed with primary lung cancer and IP using high-resolution computed tomography. Multivariable logistic regression analyses were performed to iden...
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
Abstract BACKGROUND: Interstitial pneumonia (IP) is linked to lung cancer, and treatment can cause acute exacerbation. We aimed to identify predictors of severe postoperative complications in patients with lung cancer and IP. METHODS: Between April 2007 and April 2017, 199 patients were diagnosed with primary lung cancer and IP using high-resolution computed tomography. Multivariable logistic regression analyses were performed to identify independent predictors of severe complications (Clavien-Dindo grade IIIa or higher). RESULTS: Multivariable analyses revealed that severe complications were independent...
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: Ann Thorac Surg Source Type: research
Abstract Chronic obstructive pulmonary disease (COPD) and lung cancer, closely related to smoking, are major lung diseases affecting millions of individuals worldwide. The generated gas mixture of smoking is proved to contain about 4,500 components such as carbon monoxide, nicotine, oxidants, fine particulate matter, and aldehydes. These components were considered to be the principle factor driving the pathogenesis and progression of pulmonary disease. A large proportion of lung cancer patients showed a history of COPD, which demonstrated that there might be a close relationship between COPD and lung cancer. In th...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
ConclusionPatients with a V20total lung 
Source: Thoracic Cancer - Category: Cancer & Oncology Authors: Tags: ORIGINAL ARTICLE Source Type: research
Abstract Hydrogen sulfide (H2S) has been recognized as the third endogenous signaling gasotransmitter following nitric oxide (NO) and carbon monoxide (CO), and exhibits antiproliferative activity against several cancer cells. In order to stably and controllably release H2S, H2S donating compound (ADT-OH) was used in the present study and 18H2S releasing natural ent-kaurane diterpenoid oridonin derivatives were designed and synthesized. Most derivatives showed more potent antiproliferative activities than oridonin against HepG2 and K562 cell lines, while they were lack of sensitivity to HCT-116 and B16 ce...
Source: European Journal of Medicinal Chemistry - Category: Chemistry Authors: Tags: Eur J Med Chem Source Type: research
Condition:   Liver Cancer Interventions:   Procedure: CO Testing Pre/Post Hepatic Resection;   Diagnostic Test: ABG Testing Pre/Post Hepatic Resection;   Diagnostic Test: CT Evaluations Sponsor:   University of Maryland, Baltimore Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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