Inhibition of XBP1s ubiquitination enhances its protein stability and improves glucose homeostasis

Hepatic ER stress is a risk factor of insulin resistance and type 2 diabetes. X-box binding protein 1 spliced (XBP1s), a transcription factor, plays a key role in ameliorating insulin resistance and maintaining glucose homeostasis. Unfortunately, the short half-life of the protein dampens its clinical application, and the specific site of lysine residue that could be ubiquitinated and involved in the degradation of XBP1s remains elusive.

Source: Metabolism - Clinical and Experimental - December 10, 2019 Category: Biomedical Science Authors: Honglin Sun, Gang Wei, He Liu, Danrui Xiao, Jianbo Huang, Junxi Lu, Ji Miao, Junli Liu, Suzhen Chen Source Type: research