Geometrical reorganization of Dectin-1 and TLR2 on single phagosomes alters their synergistic immune signaling [Biophysics and Computational Biology]

Receptors of innate immune cells function synergistically to detect pathogens and elicit appropriate immune responses. Many receptor pairs also appear “colocalized” on the membranes of phagosomes, the intracellular compartments for pathogen ingestion. However, the nature of the seemingly receptor colocalization and the role it plays in immune regulation are unclear,...

Source: Proceedings of the National Academy of Sciences - December 9, 2019 Category: Science Authors: Wenqian Li, Jun Yan, Yan Yu Tags: PNAS Plus Source Type: research