A Prospective Study of Sentinel Lymph Node Mapping for Endometrial Cancer: Is It Effective in High‐Risk Subtypes?

Conclusion.Cervical injection of ICG and SLN mapping yielded a low sensitivity and a high FN rate for the identification of node metastasis in endometrial cancer with high‐risk histologies.Implications for Practice.The efficacy of sentinel lymph node (SLN) mapping for high‐risk endometrial cancer remains unclear. This study enrolled 131 patients with early‐stage endometrial cancer who underwent cervical injection of indocyanine green SLN mapping followed by systematic pelvic lymphadenectomy and para‐aortic lymphadenectomy. The key result was that SLN mapping yielded a low sensitivity and a high false‐negative rate for the identification of node metastasis in endometrial cancer with high‐risk histologies. The SLN strategy in these patients may increase the risk of missed diagnosis of isolated para‐aortic node metastases and seems to be unacceptable in clinical practice.
Source: The Oncologist - Category: Cancer & Oncology Authors: Tags: Gynecologic Oncology Source Type: research