Two new xanthones from the roots of Cratoxylum cochinchinense and their cytotoxicity

AbstractTwo new xanthones namely cratochinone A (1) and cratochinone B (2), along with 16 known xanthones, were isolated from the roots ofCratoxylum cochinchinense. Their structures were characterized by spectroscopic methods, especially 1D and 2D NMR as well as comparison with those reported in the literature for known xanthones. All isolated compounds were evaluated for their cytotoxicity against five human cancer cell lines (KB, HeLa S-3, HT-29, MCF-7 and Hep G2 cell lines). Compounds2,5, and7 showed significant cytotoxic effects against all cell lines with IC50 values in the range of 0.91 –9.93 μM, while10 exhibited cytotoxicity against the KB, HeLa S-3, and HT-29 cells with IC50 values of 7.39, 6.07, and 8.11  μM, respectively. Compound12 exhibited cytotoxicity against both KB and HeLa S-3 cells with IC50 values of 7.28 and 9.84  μM.
Source: Journal of Natural Medicines - Category: Drugs & Pharmacology Source Type: research