Effects of SIMEOX on Airway Clearance in Cystic Fibrosis
Condition: Cystic Fibrosis Interventions: Other: Autogenic drainage; Device: SIMEOX + Autogenic drainage Sponsor: Cliniques universitaires Saint-Luc- Université Catholique de Louvain Recruiting
PMID: 31977412 [PubMed - in process]
Despite our differences, one thing we all have in common is death. One way or another, it's going to get each of us. Jeremie has been forced to meditate on that reality and it's had a profound effect on how he approaches life. In this keynote, Jeremie candidly and openly shares his story about growing up with Cystic Fibrosis and how he found laughter to be key as he shifted his perspective from seeing himself as someone who is dying from a fatal disease to someone who has been given the gift of a shortened life expectancy in order to make the most of it.
Trikafta, a combination of elexacaftor, ivacaftor, and tezacaftor, is a new drug for the treatment of the most common cystic fibrosis mutation.Serious adverse effects include elevated liver enzymes and an increased risk of cataracts.
CONCLUSION: Use of the CFTR modulator lumacaftor/ivacaftor was associated with significantly lower hepatic steatosis. No association between CFRD and hepatic steatosis was found in this cohort. PMID: 31966908 [PubMed]
A BEAMING Harriet Corr holds up her first box of life-saving cystic fibrosis pills, after a year of melting hearts in the Daily Express.
No abstract available
Conclusions: Constipation remains the main cause of rectal prolapse. Cystic fibrosis is no longer a common etiology for rectal prolapse, because of the implementation of newborn screening. Patients with social stressors or atypical behavior may be at risk for recurrent rectal prolapse.
Hemoptysis is a well-known complication in people with cystic fibrosis (CF), which occurs in approximately 9% of CF individuals over a 5-year time period . However, catamenial hemoptysis, expectoration of blood that coincides with menstruation, can be a unique manifestation in women with CF. Catamenial hemoptysis can be associated with thoracic endometriosis syndrome, (TES) which is estimated to occur in less than 6% of the general female population . Studies examining catamenial hemoptysis in CF are limited.
This study sought to evaluate the EFA profile in both the plasma and erythrocyte membrane according to lung status by comparing CF patients with or without a lung transplant.A total of 50 homozygous F508del patients (33 CF patients [CF group] and 17 CF patients with a lung transplant [TX CF group]) were included. In comparison with the CF group, in the plasma, the levels of total n-3, α-linolenic, eicosapentaenoic, and docosahexaenoic acids were higher and the n-6/n-3 ratio was lower in the TX CF group. Yet, these differences were not observed in the erythrocyte membrane. This study supports that lung transplantation...
ConclusionsThis systematic review and meta-analysis found good evidence for reduced antioxidant capacity and elevated oxidative stress in people with clinically-stable CF.Graphical abstract