Platelet Activation Measurements to Predict the Occurrence of Peroperative Solid Micro-emboli During Carotid Endarterectomy

Introduction: Post-operative white-matter brain lesions on diffusion-weighted magnetic resonance imaging (DWI-MRI) after carotid endarterectomy (CEA) are associated with an unfavourable neurological outcome. Up to 17% of patients undergoing CEA show new post-intervention DWI lesions. These lesions are regarded as a sign of acute ischemia and thought to be caused by both perioperative hemodynamic changes and, more importantly, by arterial micro-emboli. The main components of the micro-embolic signals (MES) that are detected with transcranial Doppler imaging (TCD) are platelet aggregates.

Source: European Journal of Vascular and Endovascular Surgery - November 30, 2019 Category: Surgery Authors: Art Brand, Tesse Leunissen, P.P. Wissman, D. van Vriesland, S.J.A. Korporaal, F.L. Moll, G. Pasterkamp, M. Roest, G.J. de Borst Source Type: research