Judging the appropriate therapy for carbapenem-resistant Acinetobacter infections.

Judging the appropriate therapy for carbapenem-resistant Acinetobacter infections. Expert Opin Pharmacother. 2019 Nov 30;:1-4 Authors: Bassetti M, Giacobbe DR PMID: 31790306 [PubMed - as supplied by publisher]
Source: Expert Opinion on Pharmacotherapy - Category: Drugs & Pharmacology Tags: Expert Opin Pharmacother Source Type: research

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Publication date: Available online 15 January 2020Source: Microbiological ResearchAuthor(s): Ashley N. Williams, John StavrinidesAbstractMulti-drug resistant Acinetobacter baumannii and Pseudomonas aeruginosa continue to pose a serious health threat worldwide. Two Pantoea agglomerans strains, 3581 and SN01080, produce an antibiotic effective against these pathogens. To identify the antibiotic biosynthetic gene clusters, independent genetic screens were conducted for each strain using a mini-Tn5 transposon, which resulted in the identification of the same conserved eight-gene cluster. We have named this antibiotic Pantoea N...
Source: Microbiological Research - Category: Infectious Diseases Source Type: research
Authors: Escolà-Vergé L, Los-Arcos I, Almirante B Abstract One of the current priorities of the World Health Organization is multidrug-resistant bacteria, because they are a global problem due to their rapid spread and the difficulty of their treatment. In addition, they are associated with high morbidity, mortality and high economic costs. There are multidrug-resistant bacteria, both Gram-positive and Gram-negative, including Pseudomonas aeruginosa and Acinetobacter baumannii resistant to carbapenems, enterobacteria producing carbapenemases, Staphylococcus aureus resistant to methicillin and/or with ...
Source: Medicina Clinica - Category: General Medicine Tags: Med Clin (Barc) Source Type: research
Acinetobacter baumannii is a gram-negative aerobic bacillus that is commonly causes of hospital-acquired infections. Community-acquired pneumonia caused by Acinetobacter baumannii (CAP-Ab) is rare but fatal if di...
Source: BMC Infectious Diseases - Category: Infectious Diseases Authors: Tags: Case report Source Type: research
Acinetobacter baumannii is a Gram-negative opportunistic pathogen with a notorious reputation of being resistant to antimicrobial agents. The capability of A. baumannii to persist and disseminate between healthca...
Source: Annals of Clinical Microbiology and Antimicrobials - Category: Microbiology Authors: Tags: Research Source Type: research
Bacteria often exist in polymicrobial communities where they compete for limited resources. Intrinsic to this competition is the ability of some species to inhibit or kill their competitors. This phenomenon is pervasive throughout the human body where commensal bacteria block the colonization of incoming microorganisms. In this regard, molecular epidemiological and microbiota-based studies suggest that species-specific interactions play a critical role in the prevention of nasal colonization of the opportunistic pathogen Staphylococcus aureus. Despite this, S. aureus exists as part of the microbiota of ∼25% of the popu...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
DNA damage response allows microorganisms to repair or bypass DNA damage and maintain the genome integrity. It has attracted increasing attention but the underlying influential factors affecting DNA damage response are still unclear. In this work, isobaric tags for relative and absolute quantification (iTRAQ)-based proteomic analysis was used to investigate the influence of carbon sources on the translational response of Acinetobacter baylyi ADP1 to DNA damage. After cultivating in a nutrient-rich medium (LB) and defined media supplemented with four different carbon sources (acetate, citrate, pyruvate, and succinate), a to...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
AbstractThe present study investigated the clinical course, treatment pattern, prognostic factors, and outcome of patients with pun-drug resistant (PDR) infections. This was a retrospective single-center cohort study including consecutive eligible patients with a PDR infection hospitalized at the University Hospital of Heraklion, Crete, Greece, between January 2010 and June 2018. In total, 65 patients with infections due to PDR gram-negative pathogens were identified. The median age was 64 years (interquartile range, IQR: 45.5 –74.5) and the median Charlson comorbidity index 3.0 (IQR: 1.0–5.75). Of the 65 PDR i...
Source: European Journal of Clinical Microbiology and Infectious Diseases - Category: Microbiology Source Type: research
AbstractThe rise of antibiotic resistance combined with the lack of new products entering the market has led to bacterial infections becoming one of the biggest threats to global health.  Therefore, there is an urgent need to identify novel antibiotic targets, such as dihydrodipicolinate synthase (DHDPS), an enzyme involved in the production of essential metabolites in cell wall and protein synthesis. Here, we utilised a 7‐residue sequence motif to identify mis‐annotation of mu ltiple DHDPS genes in the high‐priority Gram‐negative bacteria Acinetobacter baumannii and Klebsiella pneumoniae. We su...
Source: FEBS Letters - Category: Biochemistry Authors: Tags: COMMUNICATION Source Type: research
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Source: Protein Science - Category: Biochemistry Authors: Tags: Article Source Type: research
Publication date: Available online 10 January 2020Source: Journal of Environmental Chemical EngineeringAuthor(s): Oliver Terna Iorhemen, Mohamed Sherif Zaghloul, Rania Ahmed Hamza, Joo Hwa TayAbstractThe deterioration of the structural integrity of aerobic granular sludge (AGS) in long-term operation is a major limitation of the AGS biotechnology. The present study explored AGS long-term stability at semi-pilot-scale using the combined strategy of long anaerobic slow feeding, 1:3 fixed ratio of feast-famine period within each cycle, and selective discharge of mature granules. Biomass characteristics, extracellular polymeri...
Source: Journal of Environmental Chemical Engineering - Category: Chemistry Source Type: research
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