Immune cells in carotid artery plaques: what can we learn from endarterectomy specimens?

CONCLUSIONS: Since the destabilization of the atherosclerotic plaque is a multifactorial process, a combination of various methods should be used to characterize the unstable plaques more accurately. In this context, studies characterizing plaque content from a cellular point ofview could elucidate some processes underlying the plaque progression. Together with morphological evaluation, these analyses could enable more precise assessment of plaque stability. PMID: 31782285 [PubMed - as supplied by publisher]
Source: International Angiology - Category: Cardiology Tags: Int Angiol Source Type: research

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Introduction - Carotid artery stenting (CAS) is currently associated with an increased risk of 30-day stroke and death compared to carotid endarterectomy (CEA), while following this periprocedural period both interventions seem equally durable. In light of recent developments, both procedures could become equally effective in the periprocedural period. Consequently, a thorough comparison of costs and cost-effectiveness for CAS and CEA is warranted to provide arguments to support clinical decision making.
Source: European Journal of Vascular and Endovascular Surgery - Category: Surgery Authors: Source Type: research
Introduction - In patients with asymptomatic carotid artery disease receiving optimal medical treatment, carotid plaque echolucency has been shown to predict the risk of future ipsilateral stroke. Therefore, carotid endarterectomy may be more beneficial in patients with definite echolucent carotid plaque and as a result plaque echolucency has been suggested as a tool to aid in patient selection for surgery. However, carotid plaque echolucency is also thought to predict other systemic cardiovascular events (i.e.
Source: European Journal of Vascular and Endovascular Surgery - Category: Surgery Authors: Source Type: research
Introduction - A number of ultrasonic texture features which include severity of stenosis, grey scale median (GSM), plaque area (PA), juxtaluminal plaque area (JBA) and discrete white area (DWA) have been shown to be independent predictors of future strokes in carotid disease patients. The primary aim of the present study was to determine the association between histological features and ultrasonic plaque texture features after carotid endarterectomy. Secondary aim was to assess the association between statin therapy and symptomatic disease or other histological features.
Source: European Journal of Vascular and Endovascular Surgery - Category: Surgery Authors: Source Type: research
Introduction - Carotid endarterectomy (CEA) is performed to prevent strokes. Post hoc analyses of the major randomized controlled trials (RCTs) have emphasized the importance of avoiding delay prior to CEA, but of all subgroups the effect is least present in the largest of groups, male patients with a high grade stenosis (1, 2). However, in the numerous reports on national and international CEA series, patient selection data and complication rates are often reported separately. Our aim was to investigate the effect of the main individual factors on the expected effect on stroke prevention and to develop a reporting standar...
Source: European Journal of Vascular and Endovascular Surgery - Category: Surgery Authors: Source Type: research
Introduction - Three large randomised trials have assessed the efficacy and safety of carotid endarterectomy (CEA) in patients with tight carotid stenosis and no recent unilateral symptoms. Although absolute risk reductions changed over time, the trials (VA, ACAS, ACST-1; 5226 participants recruited from 1983-2003) found that stroke risk was halved by successful surgery.
Source: European Journal of Vascular and Endovascular Surgery - Category: Surgery Authors: Source Type: research
Perioperative neck hematoma (PNH) requiring re-intervention is an important complication after carotid endarterectomy (CEA). There are limited data regarding the potential risk factors associated with PNH. The aim of this prospective, multicenter study was to document the rate of PNH in symptomatic carotid artery stenosis (sCAS) patients treated with CEA within the first 14  days of cerebrovascular symptom onset and to identify possible predictors of this complication.
Source: Journal of the Neurological Sciences - Category: Neurology Authors: Source Type: research
Conclusions: Moderate to marked intraplaque neovascularization detected by SMI was more likely in subjects with a history of any territory stroke or TIA or thicker plaque. This indicates a potential new role of SMI in stratifying future risk of stroke or other arterial disease complications.
Source: Frontiers in Neurology - Category: Neurology Source Type: research
To report a single center experience with early surgical carotid revascularization in patients affected by transient ischemic attack and minor/moderate ischemic acute stroke.
Source: Annals of Vascular Surgery - Category: Surgery Authors: Tags: Clinical Research, Basic Science Source Type: research
This study aims to evaluate whether the choice of anesthesia modifies the association between shunting and in-hospital stroke/death after CEA.
Source: Journal of Vascular Surgery - Category: Surgery Authors: Source Type: research
Previously, we described a Vascular Study Group of New England (VSGNE) risk predictive model to predict composite adverse outcomes (postoperative death, stroke, myocardial infarction, or discharge to extended care facilities) after carotid endarterectomy (CEA). The goal of this study was to externally validate this model using an independent database.
Source: Journal of Vascular Surgery - Category: Surgery Authors: Source Type: research
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