Characteristics of Women With Gestational Diabetes From Non-Caucasian Compared With Caucasian Ethnic Groups

ConclusionsSeveral important ethnicity-specific differences in clinical and behavioural characteristics of women with GDM were identified. These differences need to be considered when offering interventions for reducing risk of adverse perinatal outcomes and subsequent type 2 diabetes.RésuméObjectifsLes issues à court terme et à long terme des femmes ayant eu un diabète sucré gestationnel (DSG) varient selon l’ethnicité. Comprendre les différences dans les facteurs de risques initiaux du diabète est important pour éclairer le choix quant aux interventions visant à réduire les risques. Nous avions pour objectif de comparer les caractéristiques maternelles et celles liées à la grossesse chez des femmes blanches et des femmes non blanches atteintes du DSG.MéthodesÀ partir d’une vaste cohorte multicentrique de femmes canadiennes ayant un diagnostic de DSG, et recrutées entre 2009 et 2013, nous avons comparé les caractéristiques démographiques, cliniques et comportementales des femmes atteintes du DSG de 7 groupes ethniques. Nous avons obtenu les données d’une revue de dossiers et d’enquêtes, et avons utilisé des modèles de régression linéaire pour comparer les variables binaires et continues entre les groupes d’origine ethnique blanche et les groupes d’origine...
Source: Canadian Journal of Diabetes - Category: Endocrinology Source Type: research

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Source: Biocatalysis and Agricultural Biotechnology - Category: Biotechnology Source Type: research
Publication date: Available online 18 January 2020Source: Life SciencesAuthor(s): A.J. Mouton, E.J. El Hajj, V.K. Ninh, R.W. Siggins, J.D. GardnerAbstractAimsThe purpose of this study was to investigate mechanisms of chronic alcohol-induced cardiac remodeling and dysfunction. We also sought to determine the role of cardiac fibroblasts, which play a dynamic role in cardiac remodeling, in mediating these effects.Main methodsAdult male Wistar rats were exposed to ethanol (EtOH) vapor inhalation for 16 weeks. Echocardiography was performed to assess terminal cardiac structure and function. Cardiac fibroblasts were isolated f...
Source: Life Sciences - Category: Biology Source Type: research
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Source: Process Biochemistry - Category: Biochemistry Source Type: research
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Source: Process Biochemistry - Category: Biochemistry Source Type: research
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Source: Microchemical Journal - Category: Chemistry Source Type: research
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Source: Journal of Alloys and Compounds - Category: Chemistry Source Type: research
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Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
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Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
Conclusion The expression of the components of the PTN-MK-RPTPβ/ζ axis in immune cells and in inflammatory diseases suggests important roles for this axis in inflammation. Pleiotrophin has been recently identified as a limiting factor of metainflammation, a chronic pathological state that contributes to neuroinflammation and neurodegeneration. Pleiotrophin also seems to potentiate acute neuroinflammation independently of the inflammatory stimulus while MK seems to play different -even opposite- roles in acute neuroinflammation depending on the stimulus. Which are the functions of MK and PTN in chronic neuroinfla...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
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Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
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