The Shifting Paradigm in Chronic Lymphocytic Leukemia: Is Chemotherapy Still Relevant?

The Shifting Paradigm in Chronic Lymphocytic Leukemia: Is Chemotherapy Still Relevant?
Cancer J. 2019 Nov/Dec;25(6):374-377
Authors: Jain N, OʼBrien S
Abstract
Chemoimmunotherapy (CIT) was the standard treatment for patients with chronic lymphocytic leukemia for the last 2 decades. Recently, with the introduction of targeted therapies, the role of CIT has declined significantly. In the first-line setting, the role of CIT is limited to young fit patients with mutated immunoglobulin heavy chain variable region and without del(17p)/TP53 mutation. There is a limited role for CIT in relapsed chronic lymphocytic leukemia.
PMID: 31764117 [PubMed - in process]

Source: Cancer Journal - October 31, 2019 Category: Cancer & Oncology Authors: Jain N, OʼBrien S Tags: Cancer J Source Type: research