Alternative Effective and Safe Induction Regimens for Newly Diagnosed Acute Myeloid Leukemia in Patients with Cardiac Contra-indication to Anthracyclines

Conclusion: TA, FLAG and CLARA regimens are efficient and associated with acceptable toxicity in AML patients ineligible for "3+7" regimen due to cardiac comorbidities. However, long term outcome remains disappointing highlighting the need for the development of less toxic regimens.
Source: Clinical Lymphoma Myeloma and Leukemia - Category: Cancer & Oncology Source Type: research

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Hypoxic injury is one of the most important factors in progressive kidney disorders. Since we have found that δ-opioid receptor (DOR) is neuroprotective against hypoxic stress through a differential regulation of mitogen-activated protein kinases (MAPKs) and anti-inflammatory cytokines, we asked if DOR that is highly expressed in the kidney can modulate renal MAPKs and anti-inflammatory cytokines under hypoxia. We exposed cultured rat kidney epithelial cells (NRK-52E) to prolonged hypoxia (1% O2) with applications of specific DOR agonist or/and antagonist to examine if DOR affects hypoxia-induced changes in MAPKs and...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
The immunotherapy induces a form of cell death in leukemia cells in mice that triggers cytokine release syndrome, a dangerous inflammatory reaction that occurs in some patients.
Source: The Scientist - Category: Science Tags: News & Opinion Source Type: news
Authors: Harrington P, Radia D, de Lavallade H Abstract INTRODUCTION: The outlook for patients with chronic myeloid leukaemia (CML) has changed dramatically with the development of tyrosine kinase inhibitors (TKIs) with the current treatment goal for many patients being to obtain a durable deep molecular remission, discontinue TKI therapy and remain treatment-free.Areas covered: In this article the authors review the data from the major TKI discontinuation studies, explore potential predictors of discontinuation outcome and look at possible mechanisms to explain the variable outcomes following TKI discontinuation i...
Source: Expert Review of Hematology - Category: Hematology Tags: Expert Rev Hematol Source Type: research
ConclusionBM-MSCs delivered miR-222-3p via exosomes to inhibit cell proliferation and promote cell apoptosis by targeting IRF2 and negatively regulating IRF2/INPP4B signaling in THP-1 cells.
Source: Molecular and Cellular Probes - Category: Molecular Biology Source Type: research
Not in person, as both are rather historical, but when in Paris, I encountered:Dr Alphonse LaveranandDr Paul GachetDr Laveran has a square named after him, adjacent to the Ecole de Val de Grace, a school of military medicine, where he worked after serving in the army as a physician, and where his father had held the same post.   Paris is good at telling you who a street is named after, so the street sign tells you he was the first French winner of theNobel Prize for Medicine or Physiology.  He won it for identifying both malaria and sleeping sickness as caused by parasites.Dr Gachet has aportrait in the...
Source: Browsing - Category: Databases & Libraries Source Type: blogs
BACKGROUND: Current concussion symptom inventories emphasize total number or symptoms and severity and overlap with other conditions, such as mental health disorders, which may limit their specificity and clinical utility. OBJECTIVE: To develop and...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
The 2nd Infrastar Training School will be held at Centrale Nantes in France (14-17 April 2020). The training is endorsed by IABSE, COFREND and AFGC. It aims to provide lectures and hands-on trainings to Master and PhD students, early-stage researchers, young professionals on all aspects of asset management of civil infrastructures with respect to fatigue of materials. Apply by February 11, 2020. Do not miss the opportunity to meet and discuss with: Dr Odile Abraham (Université Gustave Eiffel - Ifsttar), Dr Xavier Chapeleau (Université Gustave Eiffel - Ifsttar), Prof. Jochen Köhler (NTNU), Dr Ernst Ni...
Source: EUROPA - Research and Innovation: Events - Category: Research Tags: Marie Skłodowska-Curie Actions - 3059E6CE-E0DD-C2E8-BAD708C393829198 Research Infrastructures - D29511F7-D3D9-595F-13AA4BD57836FFBB Horizon 2020 - 719491AD-9C69-558D-B05B8AC79345ED08 Marine and aquaculture - A04D309F-A22D-5456-5F597929A790EC51 Source Type: events
This research has the potential to aid in the development of new strategies for early detection of relapse in pediatric patients with ALL, and the development of treatments to counter clinical occurrence.
Source: CancerNetwork - Category: Cancer & Oncology Authors: Source Type: news
Publication date: Available online 18 January 2020Source: International Journal for Parasitology: Parasites and WildlifeAuthor(s): Serene Yu, Joseph Modarelli, John M. Tomeček, Justin T. French, Clayton Hilton, Maria D. Esteve-GasentAbstractDetermining which wildlife hosts are involved in the enzootic cycles of tick-borne diseases (TBD) enables enhanced surveillance and risk assessment of potential transmission to humans and domestic species. Currently, there is limited data to indicate which tick-borne pathogens (TBP) can infect coyotes. Additionally, limited surveillance data for white-tailed deer (WTD) in south Texas i...
Source: International Journal for Parasitology: Parasites and Wildlife - Category: Parasitology Source Type: research
Publication date: 15 April 2020Source: Journal of Molecular Structure, Volume 1206Author(s): Imre Huber, Zsuzsanna Rozmer, Zoltán Gyöngyi, Ferenc Budán, Péter Horváth, Eszter Kiss, Pál PerjésiAbstractThe chemical susceptibility of the β-diketone linker between the two aromatic rings in the structure of curcumin to hydrolysis and metabolism has made it crucial to investigate structurally modified analogs of curcumin without such shortcomings. The synthesis of twenty cyclic C5-curcuminoids is described in this study in order to gain more insight into their anticancer struct...
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
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