Effectiveness and safety of droperidol in a United States emergency department

Droperidol is a dopamine receptor antagonist that functions as an analgesic, sedative, and antiemetic. In 2001, the U.S. Food and Drug Administration required a black box warning in response to case reports of QT prolongation and potential fatal arrhythmias. The aim of this study was to evaluate the effectiveness and safety of droperidol in patients presenting to a United States Emergency Department (ED).
Source: The American Journal of Emergency Medicine - Category: Emergency Medicine Authors: Source Type: research

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Conclusion: Regional electrophysiology and paths in the model match human action potentials, dynamic behavior, and cardiac activation sequences. Connected in closed loop with a pacing device in DDD mode, the model generates complex arrhythmia such as atrioventricular nodal reentry tachycardia. Such device-induced outcomes have been observed clinically and we can establish the key physiological features of the heart model that influence the device operation. Significance: These findings demonstrate how an abstract heart model can be used for device validation and to design personalized treatment.
Source: IEEE Transactions on Biomedical Engineering - Category: Biomedical Engineering Source Type: research
BOSTON (CBS) — Marijuana use is growing in popularity and local doctors are sounding the alarm about the potential harms the drug could have on the heart. They say marijuana carries many of the same cardiovascular risks as smoking tobacco. Researchers at Brigham and Women’s Hospital say while more patients are curbing their use of cigarettes, there has been an acceleration in marijuana use that marijuana users are now exceeding cigarette smokers. And the effects of the drug on cardiovascular health are not fully understood. Some studies have linked marijuana use with stroke, arrhythmias, and other heart conditi...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Boston News Health Healthwatch Seen On WBZ-TV Syndicated CBSN Boston Syndicated Local Dr. Mallika Marshall Marijuana Source Type: news
Men’s sexual health and wellness company, Morari Medical is using neuromodulation for its wearable device to help treat premature ejaculation (PE). The Maple Grove, MN-based company debuted a prototype of the patch-like device at the Consumer Electronics Show in Las Vegas earlier this month. Morari was one of 10 companies in the emerging sextech market to have a presence at the show. Jeff Bennett, the company’s founder and CEO spoke with MD+DI about the Morari Medical and its mission. “Specifically, we’re trying to address the medical condition of PE, ...
Source: MDDI - Category: Medical Devices Authors: Tags: Electronics Source Type: news
(Brigham and Women's Hospital) Observational studies have linked marijuana use to a range of cardiovascular risks, including stroke, arrhythmia and diseases that make it hard for the heart muscle to pump properly. The investigators encourage physicians to ask their patients about marijuana use, which can interfere with other medications that a cardiology patient might be prescribed.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
(University of Birmingham) A technique that enables patients suffering from heart conditions to hold their breath safely for over five minutes could have potential as part of a new treatment for cardiac arrhythmias, say researchers at the University of Birmingham.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
AbstractBackgroundMany of the patients who are undergoing Coronary Artery Bypass Graft have diabetes mellitus or metabolic syndrome and are at risk for hyperglycemia events.ObjectiveThe present study aimed to compare conventional glucose control with adjusted tight control in patients undergoing on-pump CABG.MethodsThis double –blind randomized clinical trial study was conducted in Shiraz, Iran, from September 2017–March 2018. Two consecutive groups of 75 patients undergoing elective on- pump coronary artery bypass graft surgery.InterventionThe patients were divided into adjusted tight control of the blood gluc...
Source: Journal of Diabetes and Metabolic Disorders - Category: Endocrinology Source Type: research
AbstractVentricular arrhythmias are an important cause of morbidity and mortality and come in a variety of forms, from single premature ventricular complexes to sustained ventricular tachycardia and fibrillation. Rapid developments have taken place over the past decade in our understanding of these arrhythmias and in our ability to diagnose and treat them. The field of catheter ablation has progressed with the development of new methods and tools, and with the publication of large clinical trials. Therefore, global cardiac electrophysiology professional societies undertook to outline recommendations and best practices for ...
Source: Journal of Interventional Cardiac Electrophysiology - Category: Cardiology Source Type: research
This study provides strong evidence that following a healthy lifestyle can substantially extend the years a person lives disease-free." Commentary on Recent Evidence for Cognitive Decline to Precede Amyloid Aggregation in Alzheimer's Disease https://www.fightaging.org/archives/2020/01/commentary-on-recent-evidence-for-cognitive-decline-to-precede-amyloid-aggregation-in-alzheimers-disease/ I can't say that I think the data presented in the research noted here merits quite the degree of the attention that it has been given in the popular science press. It is interesting, but not compelling if its role...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Publication date: Available online 18 January 2020Source: Life SciencesAuthor(s): Zhipei Liu, Yuzhong Jia, Lv Song, Youjia Tian, Peipei Zhang, Peihua Zhang, Zhenzhen Cao, Jihua MaAbstractAimsDetect the antiarrhythmic effect of crotonoside (Cro).Main methodsWe used whole-cell patch-clamp techniques to detect the effects of Cro on action potentials (APs) and transmembrane ion currents in isolated rabbit left ventricular myocytes. We also verified the effect of Cro on ventricular arrhythmias caused by aconitine in vivo.Key findingsCro reduced the maximum depolarization velocity (Vmax) of APs and shortened the action potential...
Source: Life Sciences - Category: Biology Source Type: research
This study adds to the body of evidence in describing incidence and type of cardiac events experienced by an allogeneic and autologous HSCT population at one institution from 2012-2017. Sixty-five patients (9.8%) experienced cardiac events, including atrial arrhythmia (N = 39), acute heart failure (N = 9), acute coronary syndrome (N = 7), new onset hypertension (N = 9), with a few instances of bradycardia, ventricular arrhythmia, pericardial effusion, and pericarditis. Our multivariable regression analysis identified age (older), creatinine (higher) and history of coronary artery disease to significantly correlate with ris...
Source: Clinical Lymphoma Myeloma and Leukemia - Category: Cancer & Oncology Source Type: research
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