Impact of skeletal muscle quality on two-year trajectory of exercise capacity after lung transplantation
Background: Exercise intolerance is hallmark of patients with severe respiratory diseases. Even after lung transplantation (LTx), exercise capacity may not recover fully because of existing skeletal muscle dysfunction.Aim: By tracking longitudinal clinical course, we aimed to explore determinant of long-term recovery of exercise capacity after LTx.Methods: We consecutively enrolled patients who underwent LTx at Kyoto University Hospital. Patients who performed 1-year follow-up evaluation after LTx including exercise capacity (6-minute walk distance; 6MWD) and chest CT were followed-up for additional 1 year (second year after LTx) and evaluated again at two-year after LTx. To evaluate and track skeletal muscle, we analyzed erector-spinae muscle (ESM) using chest CT images before, 1-year and 2-year after LTx. Cross-sectional area of ESM was used as index of quantity, and CT density (ESMCT) as quality of ESM.Results: In total, 85 patients were investigated. Mean 6MWD was 508m at 1-year after LTx and 531m at 2-year after LTx, with significant increases (p
Publication date: Available online 26 January 2020Source: NeuroImageAuthor(s): Nicole Geissberger, Martin Tik, Ronald Sladky, Michael Woletz, Anna-Lisa Schule, David Willinger, Christian WindischbergerAbstractDespite its importance as the prime method for non-invasive assessment of human brain function, functional MRI (fMRI) was repeatedly challenged with regards to the validity of the fMRI-derived brain activation maps. Amygdala fMRI was particularly targeted, as the amygdala's anatomical position in the ventral brain combined with strong magnetic field inhomogeneities and proximity to large vessels pose considerable obst...
CONCLUSIONS In the natural sitting position, a reduction in LL was associated with TK, SVA and PT increased, and there were differences between men and women. The characteristics of spinopelvic alignment in healthy older adults should be considered when planning corrective spinal surgery. PMID: 31981456 [PubMed - in process]
CONCLUSIONS Our results showed that sarcopenia was significantly and independently associated with cognitive decline and falls, but not associated with hospitalization, in the community-dwelling oldest old. PMID: 31980594 [PubMed - in process]
This article attempts to aid clinicians in using diabetes devices in their clinical practice. It reviews device selection, initiation, and follow-up. It discusses work flow in an office and provides tips on billing. It stresses the need for patient choice, education, and on-going support through downloading and interpretation of data to optimize care. PMID: 31980122 [PubMed - in process]
CONCLUSION: The use of ROBINS-I in GRADE assessments may allow for a better comparison of evidence from randomized controlled trials (RCTs) and nonrandomized studies (NRSs) because they are placed on a common metric for risk of bias. Challenges remain, including appropriate presentation of evidence from RCTs and NRSs for decision-making and how to optimally integrate RCTs and NRSs in an evidence assessment. PMID: 31980320 [PubMed - as supplied by publisher]
Publication date: Available online 25 January 2020Source: Biosensors and BioelectronicsAuthor(s): Mateusz Śmietana, Marcin Koba, Petr Sezemsky, Katarzyna Szot-Karpińska, Dariusz Burnat, Vitezslav Stranak, Joanna Niedziółka-Jönsson, Robert BogdanowiczAbstractIn this work we discuss a new label-free biosensing device based on indium tin oxide (ITO) overlaid section of a multimode optical fiber fused silica core. The sensor has been used to optical measurements also simultaneously interrogated electrochemically (EC). Due to optimized thickness and optical properties of ITO film, a lossy-mode resonance (LMR) cou...
CONCLUSION: Our study suggests the clinical efficiency of belimumab in a series of 7 patients presenting a resistant and progressive CLE. PMID: 31980188 [PubMed - as supplied by publisher]
CONCLUSION: We report a case of chronic enterovirus infection associating meningitis and myofasciitis in an adult with rituximab-induced hypogammaglobulinemia. Outcome was favorable under treatment with intravenous immunoglobulins. PMID: 31980187 [PubMed - as supplied by publisher]
Authors: Fournier E Abstract Carpal tunnel syndrome (CTS) is too common a condition not to daily interact with the practitioner, if only because of its entanglement to other pathologies, causal or chance association. The typical symptomatology, with hand paresthesia and morning pain upon waking, is related to a median nerve injury in the confined space of the carpal tunnel, more often by local inflammation and tenosynovitis of the finger flexors (repetitive activity of the hands). SCC may be secondary to situations (pregnancy) or conditions (edema, hypothyroidism…), which exaggerate the ordinary pathophysiol...
CONCLUSION: In the face of an unexplained polycythemia a good cooperation between clinicians and biologists is necessary to be able to characterize rare hereditary pathologies. PMID: 31980185 [PubMed - as supplied by publisher]