Intranasal treatment of vitamin B 12 deficiency in children

Conclusion: In children, intranasal application of vitamin B12 seems a safe and effective alternative to intramuscular injections, leading to higher compliance and less burden to patients.What is Known:• Children with vitamin B12deficiency are traditionally treated with intramuscular cobalamin injections, which are costly and painful.• Studies in adults showed that intranasal application of hydroxocobalamin leads to normalisation of vitamin B12levels.What is New:• The intranasal application of vitamin B12resulted in a substantial increase of the mean baseline vitamin B12levels without any side effect.• These data encourage a systematic evaluation of intranasal treatment of vitamin B12deficiency in order to define safety, optimal dosage and administration frequency.
Source: European Journal of Pediatrics - Category: Pediatrics Source Type: research

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In Reply Dr Auerbach takes issue with the treatment of a patient with vitamin B12 and iron deficiency after gastric bypass with oral iron. His claim that all patients who undergo bariatric surgery have an obligate need for parenteral iron because of poor absorption or increased risk with oral iron supplementation lacks clinical nuance and scientific evidence.
Source: JAMA - Category: General Medicine Source Type: research
To the Editor In a JAMA Diagnostic Test Interpretation article, Dr Murali described a patient with combined vitamin B12 and iron deficiency after bariatric surgery. The patient had a low mean corpuscular volume because the iron deficiency was primary. I am concerned about the recommendation to prescribe 60 mg of oral iron twice daily. In the section on the treatment of adults with iron deficiency on the UpToDate website, oral iron is specifically proscribed. Ingested iron must be conjugated to vitamin C, amino acids, and sugars in the presence of gastric acid in the stomach to protect the iron from the alkaline secretions ...
Source: JAMA - Category: General Medicine Source Type: research
VITAMIN B12 is an essential nutrient that supports a number of vital functions in the body so lacking the vitamin can lead to a number of unsettling complications. A lesser-known sign of a vitamin B12 deficiency can show up in your eyes.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
CONCLUSION: Paradoxical elevation of MMA with normal or elevated serum B12 is common in children with SBS. Caution should be used when interpreting serum B12 and MMA values in this setting. This may be related to effects of small-bowel bacterial overgrowth, a condition commonly seen in these patients. PMID: 31985849 [PubMed - as supplied by publisher]
Source: JPEN Journal Of Parenteral And Enteral Nutrition - Category: Nutrition Authors: Tags: JPEN J Parenter Enteral Nutr Source Type: research
VITAMIN B12 is crucial nutrient that helps maintain healthy blood and nerve cells. When there is a lack of it circulating inside the body, abnormally large red blood cells are formed that can't function properly. Eventually, this will lead to health complications - what are the signs you're deficient in vitamin B12?
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
VITAMIN B12 is a crucial vitamin needed for healthy nerve tissue health, brain function and the production of red blood cells. With more and more people making the decision to become vegan, its important to know what vegan foods contain vitamin B12. What are five vegan foods one can eat to prevent a deficiency?
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Conclusion: The prevalence of B12 deficiency, hyperhomocysteinemia, and incidence of PN among our patients is very less when compared to the Western population. The conjecture that PN in PD patients may be secondary to B12 deficiency/hyperhomocysteinemia stands as a speculation.
Source: Annals of Indian Academy of Neurology - Category: Neurology Authors: Source Type: research
Conclusions: Our study indicates that a significant increase in ADC values occurs in multiple brain regions in patients with vitamin B12.
Source: Annals of Indian Academy of Neurology - Category: Neurology Authors: Source Type: research
VITAMIN B12 is a vital nutrient the body needs to be on top form. It ’s needed for nerve tissue health, brain function and the production of red blood cells. Take a look in the mirror to see if you’re missing this important nutrient.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
VITAMIN B12 is an essential nutrient that helps the body to function properly so lacking the vitamin can trigger a wave of symptoms. A B12 deficiency can show up in the digestive tract, causing a change in your toilet habits.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
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