A non-epidermolytic keratinocytic epidermal naevus associated with a post-zygotic mutation in the gene encoding the epidermal growth factor receptor.

A non-epidermolytic keratinocytic epidermal naevus associated with a post-zygotic mutation in the gene encoding the epidermal growth factor receptor. Br J Dermatol. 2019 Nov 20;: Authors: Umegaki-Arao N, Ono N, Tanaka R, Sasaki T, Fujita H, Shiohama A, Aoki S, Amagai M, Kubo A Abstract Non-epidermolytic keratinocytic epidermal nevi (KEN) are benign congenital skin lesions exhibiting verrucous acanthosis and hyperkeratosis characterized by a linear distribution along the lines of Blaschko. Non-epidermolytic KEN arise as a result of prenatal postzygotic mutations in components of either the rat sarcoma (RAS)/mitogen-activated protein kinase (MAPK) pathway or phosphoinositide-3 kinase (PI3K)/AKT pathway. PMID: 31745974 [PubMed - as supplied by publisher]
Source: The British Journal of Dermatology - Category: Dermatology Authors: Tags: Br J Dermatol Source Type: research