New cytotoxic limonoids from the stem bark of Chisocheton pentandrus (Blanco) Merr

Publication date: February 2020Source: Phytochemistry Letters, Volume 35Author(s): Unang Supratman, Supriatno Salam, Wiro Naibaho, Mohamad Fajar, Nurlelasari, Dewa Gede Katja, Desi Harneti, Rani Maharani, Ace Tatang Hidayat, Ronny Lesmana, Mohamad Azlan Nafiah, Yoshihito ShionoAbstractThree new limonoids namely pentandricines B–D (1–3), were isolated from n-hexane extract of the stem bark of Chisocheton pentandrus, along with four known limonoids (4-7). The chemical structures of pentandricines B–D, were fully elucidated based on UV, IR, HR-TOFMS, 1D- and 2D-NMR spectra. Furthermore, compounds 1-7 were evaluated for their cytotoxic activity against MCF-7 breast cancer cells in vitro, with compound 7 (nimonol) showing strongest cytotoxicity activity with an IC50 value of 22.03 ± 0.026 μM.Graphical abstract
Source: Phytochemistry Letters - Category: Chemistry Source Type: research