Time to Rethink Ideas About Exercise, Sickle Cell Disease?

Title: Time to Rethink Ideas About Exercise, Sickle Cell Disease?Category: Health NewsCreated: 11/19/2019 12:00:00 AMLast Editorial Review: 11/20/2019 12:00:00 AM
Source: MedicineNet Chronic Pain General - Category: Anesthesiology Source Type: news

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Title: Sickle Cell Disease (Anemia)Category: Diseases and ConditionsCreated: 12/31/1997 12:00:00 AMLast Editorial Review: 1/10/2020 12:00:00 AM
Source: MedicineNet Chronic Pain General - Category: Anesthesiology Source Type: news
Authors: Sackner MA, Lopez JR, Banderas V, Adams JA Abstract This review deals with opioid addiction, chronic pain, and an innovative, noninvasive technology with simultaneous, beneficial applications for both conditions. This technology, called passive simulated jogging device (GENTLE JOGGER, JD) targets addiction and pain by increasing endothelial nitric oxide (NO) bioavailability. It can be self-administered while sitting or lying without resorting to multitasking thereby allowing watching television or operating a computer while effortless, physical activity is produced from motorized foot pedals repetitively s...
Source: Journal of Opioid Management - Category: Addiction Tags: J Opioid Manag Source Type: research
Authors: Smith-Whitley K Abstract Pregnancy in women with sickle cell disease (SCD) is associated with increased maternal and fetal morbidity and mortality. Outcomes vary widely owing to methodological limitations of clinical studies, but overall, hypertensive disorders of pregnancy, venothromboembolism, poor fetal growth, and maternal and perinatal mortality are increased globally. Few therapeutic interventions have been explored other than prophylactic and selective transfusion therapy. Unfortunately, existing data are limited, and it remains unclear whether prophylactic use of chronic transfusions will improve p...
Source: Hematology ASH Education Program - Category: Hematology Tags: Hematology Am Soc Hematol Educ Program Source Type: research
We present the case of a young woman with bilateral osteonecrosis of the femoral head at varying stages of progression; we also highlight other important comorbid complications (eg, chronic pain requiring long-term opioids, debility, and social isolation) and postoperative outcomes. In this review, partly based on recommendations on osteonecrosis management from the 2014 evidence-based report on sickle cell disease from the National Heart, Lung and Blood Institutes, we also discuss early signs or symptoms of osteonecrosis of the femoral head, radiographic diagnosis and staging criteria, hydroxyurea effect on progression to...
Source: Hematology ASH Education Program - Category: Hematology Tags: Hematology Am Soc Hematol Educ Program Source Type: research
Title: FDA Approves Oxbryta for Treatment of Sickle Cell DiseaseCategory: Health NewsCreated: 11/27/2019 12:00:00 AMLast Editorial Review: 11/27/2019 12:00:00 AM
Source: MedicineNet Chronic Pain General - Category: Anesthesiology Source Type: news
A 46-year-old woman with a history of sickle cell disease and associated predialysis stage V chronic kidney disease (CKD) with secondary hyperparathyroidism presented with fever, severe extremity pain, and perioral numbness. On examination, she had a prominent Chvostek ’s sign, carpopedal spasm, hyperactive tendon reflexes, and a nontender mass in the left lobe of her thyroid gland. She was not on bisphosphonates or calcimimetics and had not been taking her prescribed calcitriol for 2 weeks.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Make Your Diagnosis Source Type: research
Title: New Sickle Cell Disease Drug Approved by FDACategory: Health NewsCreated: 11/18/2019 12:00:00 AMLast Editorial Review: 11/19/2019 12:00:00 AM
Source: MedicineNet Chronic Pain General - Category: Anesthesiology Source Type: news
This article represents the findings from the queries over the first three months ’ queries and brings further clarity to our initial findings.Methods This quality improvement (QI) project was reviewed and approved by the Orlando Health/UFHealth Cancer Center Joint Oncology Committee for 2018-19. We began recording results of all E-FORSCE queries occurring after the law ’s implementation of July 1, 2018 through September 30, 2018. We informed each patient that the PDMP query had become mandatory in Florida, and we discussed the results of each query with each patient. Each query examined the last 12 months of t...
Source: Pallimed: A Hospice and Palliative Medicine Blog - Category: Palliative Care Tags: kollas opioid pain quality improvement statte Source Type: blogs
Until recent findings that sickle cell disease (SCD) pain has characteristics consistent with central or peripheral sensitization,12,27,28,43 it was typically viewed as acute or persistent pain and treated mostly with opioids. Often the etiology of SCD pain is thought to be only episodic, driven by vaso-occlusion and somatic or visceral tissue damage,1,2,4 however, it has become increasingly clear that adults with SCD also experience chronic pain. A growing body of evidence now supports,12,27,28,40,43, but is not conclusive, that sensitization contributes to chronic pain in some adults with SCD.
Source: The Journal of Pain - Category: Materials Science Authors: Source Type: research
Abstract Sickle cell disease (SCD) is among the most common genetic diseases in the United States, affecting approximately 100,000 people. In the United States, SCD is characterized by a shortened life expectancy of only about 50 years in severe subtypes, significant quality-of-life impairments, and increased healthcare utilization and spending. SCD is characterized by chronic hemolytic anemia, vaso-occlusion, and progressive vascular injury affecting multiple organ systems. The pathophysiology is directly related to polymerization of deoxygenated hemoglobin, leading to a cascade of pathologic events including ery...
Source: The American Journal of Managed Care - Category: Health Management Authors: Tags: Am J Manag Care Source Type: research
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