Role Reversal: A Pro-metastatic Function of E-Cadherin.

Role Reversal: A Pro-metastatic Function of E-Cadherin.
Dev Cell. 2019 Nov 18;51(4):417-419
Authors: Shen M, Kang Y
Abstract
Carcinoma cells often acquire mobility and invasiveness by undergoing epithelial-to-mesenchymal transition, and yet most metastatic lesions remain epithelial in nature. Recently, in Nature, Padmanaban et al. (2019) demonstrated that the quintessential epithelial marker E-cadherin promotes metastasis of invasive ductal breast carcinoma by enhancing the survival of tumor cells.
PMID: 31743661 [PubMed - in process]

Source: Developmental Cell - November 17, 2019 Category: Cytology Authors: Shen M, Kang Y Tags: Dev Cell Source Type: research