Unlocking the secrets of badger dispersal to minimize the spread of bovine TB

(Trinity College Dublin) By understanding how, when, and why badgers move from one social group to another, researchers hope information gleaned from GPS devices will help them tailor vaccination programs to reduce the spread of bovine tuberculosis.
Source: EurekAlert! - Biology - Category: Biology Source Type: news

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ConclusionGains can be attained by targeting DM individuals with interventions to reduce TB burden. Most strategies were effective with
Source: Epidemics - Category: Epidemiology Source Type: research
In this study, we evaluate whether the immune responses induced by this novel vaccine might be elevated by a recombinant DNA vaccine expressing the same antigen in a heterologous prime-boost vaccination strategy. The results showed that both SeV85AB prime-DNA boost (SeV85AB-DNA) and DNA prime-SeV85AB boost (DNA-SeV85AB) vaccination strategies significantly enhanced the antigen-specific T cell responses induced by the separate vaccines. The SeV85AB-DNA immunization regimen induced higher levels of recall T cell responses afterMtb infection and conferred better immune protection compared with DNA-SeV85AB or a single immuniza...
Source: Journal of Molecular Medicine - Category: Molecular Biology Source Type: research
Authors: Shaikh BT, Hafeez A, Ali N Abstract In Pakistan, the Health and Population Think Tank was launched as an initiative to conduct programmes and policy analysis, as well as give an insight into the possible future policy options on various national health issues relevant to all the provinces. This forum has also served as a platform to discuss how provincial strategies could be aligned with the National Health Vision 2016-2025, which was developed with the consensus of all provinces and development partners. Main topics chosen for the round tables included local production of vaccines; social health protectio...
Source: Eastern Mediterranean Health Journal - Category: Middle East Health Tags: East Mediterr Health J Source Type: research
The Bacillus Calmette-Guérin (BCG) is a live attenuated tuberculosis vaccine that has the ability to induce non-specific cross-protection against pathogens that might be unrelated to the target disease. Vaccination with BCG reduces mortality in newborns and induces an improved innate immune response against microorganisms other than Mycobacterium tuberculosis, such as Candida albicans and Staphylococcus aureus. Innate immune cells, including monocytes and natural killer (NK) cells, contribute to this non-specific immune protection in a way that is independent of memory T or B cells. This phenomenon associated with a...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
A modified version of the BCG vaccine against tuberculosis could allow cattle around the world to be vaccinated against the disease
Source: New Scientist - Health - Category: Consumer Health News Source Type: research
(University of Surrey) Scientists at the University of Surrey have developed a novel vaccine and complementary skin test to protect cattle against bovine tuberculosis (bovine TB).
Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news
By Margarite Nathe, Principal Editor/Writer, IntraHealth International ; Lucy Mphuru, Country Director&Project Director, Tohara Plus Project Lucy Mphuru (center left) talks with health workers and clients at an IntraHealth-supported mobile clinic in Shinyanga that provides voluntary male circumcision services. Photo by Trevor Snapp for IntraHealth International.November 26, 2019Lucy Mphuru has a big job.Every day, she and her team at IntraHealth International in Tanzania work with frontline health workers and government partners to improve health services in a country of 58 million—1.6 million of whom live ...
Source: IntraHealth International - Category: International Medicine & Public Health Authors: Tags: HIV & AIDS Community Engagement Leadership and Governance World AIDS Day Health Workforce Systems Source Type: news
Unconventional T cell subsets, including donor-unrestricted T cells (DURTs) and γδ T cells, are promising new players in the treatment and prevention of infectious diseases. In this issue of the JCI, Ogongo et al. used T cell receptor (TCR) sequencing to characterize unconventional T cell subsets in surgical lung resections and blood from Mycobacterium tuberculosis–infected (Mtb-infected) individuals with and without HIV coinfection. The study revealed highly localized expansions of γδ T cell clonotypes not previously associated with the immune response to Mtb and demonstrates the power of hig...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Unconventional T cells that recognize mycobacterial antigens are of great interest as potential vaccine targets against tuberculosis (TB). This includes donor-unrestricted T cells (DURTs), such as mucosa-associated invariant T cells (MAITs), CD1-restricted T cells, and γδ T cells. We exploited the distinctive nature of DURTs and γδ T cell receptors (TCRs) to investigate the involvement of these T cells during TB in the human lung by global TCR sequencing. Making use of surgical lung resections, we investigated the distribution, frequency, and characteristics of TCRs in lung tissue and matched blood ...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Publication date: Available online 22 November 2019Source: Progress in Biophysics and Molecular BiologyAuthor(s): Thomas D. Crosskey, Katherine S.H. Beckham, Matthias WilmannsAbstractTuberculosis (TB) remains the foremost cause of death by infectious disease and is propagated by the pathogen Mycobacterium tuberculosis (Mtb). The virulence associated with Mtb is mediated by proteins secreted into host cells by the type VII secretion system (T7SS), making this system a candidate for future drug and vaccine development. However, while many of the components involved in the T7SS have been identified, the mechanism of transloca...
Source: Progress in Biophysics and Molecular Biology - Category: Molecular Biology Source Type: research
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