Interstitial Lung Disease: Update on the Role of Computed Tomography in the Diagnosis of Idiopathic Pulmonary Fibrosis

Idiopathic pulmonary fibrosis is the commonest interstitial lung disease. Radiologists play an essential role in making an accurate diagnosis, and this is necessary given its prognostic implications and potential use of antifibrotic therapies. This review highlights the radiologic features and imaging classification of fibrosis with reference to recently updated international guidelines and emphasizing the importance of the multidisciplinary team in idiopathic pulmonary fibrosis diagnosis and, in particular, when pathological sampling is required.
Source: Journal of Computer Assisted Tomography - Category: Radiology Tags: Cardiothoracic Imaging Source Type: research

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ConclusionsMost KS-ILD patients showed a tendency for chronic disease onset and long-term stabilization of pulmonary function.
Source: Respiratory Investigation - Category: Respiratory Medicine Source Type: research
In this study, we retrospectively analysed clinical, radiological and immunological data of a cohort of 42 patients affected by cHP: KL-6 concentrations were collected from serum and BAL. KL-6 clinical value was assessed through the analysis of association between KL-6 concentrations and clinical, functional, immunological and radiological features. KL-6 serum concentration results increased in 28/34 patients (82%). A positive direct correlation was observed between KL-6 concentrations in BAL and serum (r = 0.62,p 
Source: Internal and Emergency Medicine - Category: Emergency Medicine Source Type: research
CONCLUSIONS: This study indicated that the prevalence of ILD was high in CADM. Asymptomatic ILD has been previously underestimated. Anti-MDA5 was a risk factor for the presence of A/SIP, and CYFRA21-1 was a risk factor for ILD. PMID: 32049748 [PubMed - as supplied by publisher]
Source: Chinese Medical Journal - Category: General Medicine Authors: Tags: Chin Med J (Engl) Source Type: research
Publication date: Available online 7 February 2020Source: Respiratory Medicine Case ReportsAuthor(s): Kota Murohashi, Yu Hara, Ayako Aoki, Masahito Matsumura, Toshiro Kataoka, Koji Okudela, Takeshi KanekoAbstractAn 83-year-old man with a history of interstitial lung disease (ILD) presented with a 1-week history of progressive dyspnea. Computed tomography of the chest revealed right lung-predominant, diffuse, ground glass opacities superimposed upon reticular opacities. Despite methylprednisolone pulse therapy under a diagnosis of acute exacerbation (AE) of ILD, lung involvement and renal dysfunction worsened and disseminat...
Source: Respiratory Medicine Case Reports - Category: Respiratory Medicine Source Type: research
The first evidence-based consensus statements for systemic sclerosis-associated interstitial lung disease (SSc-ILD) recommend use of high-resolution computed tomography (CT) for screening and diagnosis, and offer guidance on when to initiate or escalate emerging treatment options.Reuters Health Information
Source: Medscape Radiology Headlines - Category: Radiology Tags: Rheumatology News Source Type: news
as IO Abstract RATIONALE: Although relatives of patients with familial pulmonary fibrosis (FPF) are at an increased risk for interstitial lung disease (ILD), the risk among relatives of sporadic pulmonary fibrosis (PF) is not known. OBJECTIVES: To identify the prevalence of interstitial lung abnormalities (ILA) and ILD among relatives of patients with FPF and sporadic PF. METHODS: Undiagnosed first-degree relatives of patients with PF consented to participate in a screening study that included the completion of questionnaires, pulmonary function testing (PFT), chest computed tomography (CT), a blood samp...
Source: Respiratory Care - Category: Respiratory Medicine Authors: Tags: Am J Respir Crit Care Med Source Type: research
Abstract RATIONALE: The pre-clinical natural history of progressive lung fibrosis is poorly understood. OBJECTIVES: Our goal was to identify risk factors for interstitial lung abnormalities (ILA) on high-resolution computed tomography (HRCT) scans, and determine progression towards clinical interstitial lung disease (ILD) among participants in a longitudinal cohort of self-reported unaffected first-degree relatives of patients with familial interstitial pneumonia. METHODS: Enrollment evaluation included health/exposure questionnaire and HRCT, which were categorized by visual assessment as no ILA, early/m...
Source: Respiratory Care - Category: Respiratory Medicine Authors: Tags: Am J Respir Crit Care Med Source Type: research
CONCLUSION: Post-deployment pulmonary evaluation should focus on common diseases such as asthma and airway hyperreactivity, and include testing for upper airway disorders. Diffuse lung diseases were rarely diagnosed while numerous co-morbidities were common. PMID: 32017933 [PubMed - as supplied by publisher]
Source: Chest - Category: Respiratory Medicine Authors: Tags: Chest Source Type: research
The prevailing view is that exertional dyspnoea in patients with combined idiopathic pulmonary fibrosis (IPF) and emphysema (CPFE) can be largely explained by severe hypoxaemia. However, there is little evidence to support these assumptions. We prospectively contrasted the sensory and physiological responses to exercise in 42 CPFE and 16 IPF patients matched by the severity of exertional hypoxaemia. Emphysema and pulmonary fibrosis were quantified using computed tomography. Inspiratory constraints were assessed in a constant work rate test: capillary blood gases were obtained in a subset of patients. CPFE patients had lowe...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Lung structure and function, Interstitial and orphan lung disease Original Articles: Interstitial lung disease Source Type: research
ConclusionsCALIPER quantification of fibrosis and vascular involvement could distinguish disease progression in treated versus untreated patients and predict the survival. The changes in CALIPER-derived variables over time were significantly correlated to changes in FVC.
Source: European Journal of Radiology - Category: Radiology Source Type: research
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