Sweet Inhibition of Zika and Dengue via 60Fullero-Dendrimers

Synfacts 2019; 15: 1375- DOI: 10.1055/s-0039-1691267 © Georg Thieme Verlag Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Full text
Source: Synfacts - Category: Chemistry Tags: Synthesis of Materials and Unnatural Products Source Type: research

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Source: virology blog - Category: Virology Authors: Tags: This Week in Virology antibody neutralization cryo-EM dengue virus flavivirus fusion loop glycoprotein Semliki Forest virus tick borne encephalitis virus viral viral membrane fusion viruses X-ray crystallography zika virus Source Type: blogs
Authors: Dávila XA, Olivera EYG, Vásquez BNZ, Romaní F PMID: 31800952 [PubMed - in process]
Source: Revista Peruana de Medicina de Experimental y Salud Publica - Category: International Medicine & Public Health Tags: Rev Peru Med Exp Salud Publica Source Type: research
This study aimed to investigate the presence of Zika, Dengue and Chikungunya viruses in Ae. aegypti and Ae. albopictus from the municipalities of Alto Alegre, Caxias, Codó, and São Mateus do Maranhão, located in the state of Maranhão, Northeast Brazil. The mosquitoes were collected with a mechanical aspirator, identified, triturated, and then submitted to RNA extraction and RT-qPCR. The positive samples were confirmed by virus isolation and genome sequencing. Three hundred and forty-eight Ae. aegypti (176 males and 172 females) and 12 Ae. albopictus (eight males and four females)...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
Conclusions/SignificanceOur results shed insights into the role ofompA gene in host-microbe interactions inAe.aegypti and confirm that CRISPR/Cas9 gene editing can be employed for genetic manipulation of non-model gut microbes. The ability to use this technology for site-specific integration of genes into the symbiont will facilitate the development of paratransgenic control strategies to interfere with arboviral pathogens such Chikungunya, dengue, Zika and Yellow fever viruses transmitted byAedes mosquitoes.
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
Publication date: Available online 28 November 2019Source: Antiviral ResearchAuthor(s): Diana Montes-Grajales, Henry Puerta-Guardo, Diego A. Espinosa, Eva Harris, William Caicedo-Torres, Jesus Olivero-Verbel, Esperanza Martínez-RomeroAbstractArboviral diseases caused by dengue (DENV), Zika (ZIKV) and chikungunya (CHIKV) viruses represent a major public health problem worldwide, especially in tropical areas where millions of infections occur every year. The aim of this research was to identify candidate molecules for the treatment of these diseases among the drugs currently available in the market, through in silico ...
Source: Antiviral Therapy - Category: Virology Source Type: research
This report shows the need for an efficient surveillance system to control the spread of this virus in the population and suggests the use of saliva and urine samples as an alternative for the detection of OROV when serum samples are not available. PMID: 31787741 [PubMed - as supplied by publisher]
Source: Japanese Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: Jpn J Infect Dis Source Type: research
Several recent studies in this journal have highlighted the threat posed by mosquito-borne viruses in China, such as Zika virus and dengue virus.1-3 Getah virus (GETV) is also a mosquito-borne virus that is classified in the Alphavirus genus of the Togaviridae family. The genome of GETV is linear, positive-sense ssRNA, encoding a total of nine viral proteins (nsP1-nsP4, E1-E3, C, and 6K). GETV was first isolated from Culex mosquitoes collected in Malaysia in 1955 and has since been found in mosquitoes in Asian countries surrounded by the Pacific Ocean (China, Japan, South Korea, Mongolia, Russia, and India) based on viral ...
Source: Journal of Infection - Category: Infectious Diseases Authors: Tags: Letter to the Editor Source Type: research
ero E Abstract Arboviral diseases caused by dengue (DENV), Zika (ZIKV) and chikungunya (CHIKV) viruses represent a major public health problem worldwide, especially in tropical areas where millions of infections occur every year. The aim of this research was to identify candidate molecules for the treatment of these diseases among the drugs currently available in the market, through in silico screening and subsequent in vitro evaluation with cell culture models of DENV and ZIKV infections. Numerous pharmaceutical compounds from antibiotics to chemotherapeutic agents presented high in silico binding affinity for th...
Source: Antiviral Research - Category: Virology Authors: Tags: Antiviral Res Source Type: research
AbstractPurpose of ReviewIn this review, we present the overview of emerging and neglected viruses associated with liver involvement.Recent FindingsHepatitis E virus (HEV) emerged in the last two decades, causing hepatitis in many parts of the world. Moreover, liver involvement was also described in some emerging arboviral infections. Many reports showed dengue-associated liver injury; however, chikungunya, West Nile, tick-borne encephalitis, and Zika virus are rarely associated with clinically manifest liver disease. In addition, some neglected highly prevalent viruses such as adenoviruses and parvovirus B19 are capable o...
Source: Current Infectious Disease Reports - Category: Infectious Diseases Source Type: research
ra AB Abstract The hexane and ethanol extracts from Himatanthus bracteatus (Apocynaceae) stems were evaluated for antiviral activity against Zika virus, yellow fever virus and dengue virus 2 and for cytotoxicity in Vero cells by MTT assay. The ethanol extract showed good antiviral activity against the three viruses with selective indexes (SI)> 10 and its fractionation led to the isolation of the known plumieride that was active only against Zika virus (SI of 15.97). PMID: 31746240 [PubMed - as supplied by publisher]
Source: Natural Product Research - Category: Biochemistry Authors: Tags: Nat Prod Res Source Type: research
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