Increased urinary excretion of hedgehog interacting protein (uHhip) in early diabetic kidney disease

Glomerular endothelial cell (GEC) dysfunction occurs in diabetic kidney disease (DKD) and generally precedes albuminuria. We recently reported that hedgehog interacting protein (Hhip), highly expressed in GECs, contributes to DKD development in diabetic mice. Here, we hypothesized that urinary Hhip (uHhip) could identify early DKD; we tested uHhip in mice and humans with diabetes (DM). In both type 1 (Akita) and type 2 (db/db) DM mice, uHhip is elevated prior to the development of albuminuria, while non-DM controls excrete minimal amount of uHhip.

Source: Translational Research - November 17, 2019 Category: Research Authors: Kana N. Miyata, Xin-Ping Zhao, Shiao-Ying Chang, Min-Chun Liao, Chao-Sheng Lo, Isabelle Chenier, Jean Ethier, Jean-Francois Cailhier, Jean-Baptiste Lattouf, Stephan Troyanov, Jean-Louis Chiasson, Julie R. Ingelfinger, John S.D. Chan, Shao-Ling Zhang Source Type: research