Immunohistochemical and Morphological Study of Periodontal Tissues in Predicting the Results of Dental Implantation in Patients with Chronic Periodontitis.

Immunohistochemical and Morphological Study of Periodontal Tissues in Predicting the Results of Dental Implantation in Patients with Chronic Periodontitis.
Dokl Biol Sci. 2019 Sep;488(1):156-159
Authors: Kulakov AA, Kogan EA, Brailovskaya TV, Vedyaeva AP, Zharkov NV
Abstract
Morphological and immunohistochemical examination was made on 24 gum biopsies obtained from 35- to 60-year-old patients with diagnosis of partial secondary adentia, chronic generalized moderate to severe periodontitis (19 patients), as well as on the biopsy samples from five patients without pathological periodontal changes who underwent dental implantation. Serial paraffin sections were treated with antibodies against Ki-67, VEGF, and SMA. In patients with severe chronic periodontitis, a high proliferative activity of epithelium indicative of hyperplastic changes was observed, as well as a reduced number of the SMA-positive cells and actual absence of the SMA-positive cell couplings associated with the "growth zones" in tissues, which testifies indirectly to a lower tissue regenerative capacity. Hence, before dental implantation, additional anti-inflammatory and pro-regenerative treatment is required.
PMID: 31732903 [PubMed - in process]

Source: Doklady Biological Sciences - August 31, 2019 Category: Biology Authors: Kulakov AA, Kogan EA, Brailovskaya TV, Vedyaeva AP, Zharkov NV Tags: Dokl Biol Sci Source Type: research