Design, synthesis, and anticancer evaluation of 1,2,4-oxadiazole functionalized quinoline derivatives

AbstractA library of 1,2,4-oxadiazole functionalized quinoline derivatives (13a –j) were synthesized and their structures were confirmed by1H NMR,13CNMR and Mass Spectral analysis. Further, these compounds were evaluated for their anticancer activity against four human cancer cell lines, namely MCF-7 (breast), A549 (lung), DU-145 (prostate) and MDA MB-231 (breast) using Etoposide as the positive control. Most of these derivatives exhibited more potent activity towards the four cancer cell lines compared to Etoposide. Amongst all the compounds tested, compounds13b, 13c, 13h, 13i and13j exhibited promising activity. Further of these compounds13b, 13i and13j exhibited excellent activity, when compared with Etoposide.
Source: Medicinal Chemistry Research - Category: Chemistry Source Type: research