Effects of l-theanine on glutamine metabolism in enterotoxigenic Escherichia coli (E44813)-stressed and non-stressed rats

Publication date: Available online 15 November 2019Source: Journal of Functional FoodsAuthor(s): An Liu, Zhihua Gong, Ling Lin, Wei Xu, Tuo Zhang, Sheng Zhang, Yinhua Li, Jinhua Chen, Wenjun XiaoAbstractl-theanine, a non-protein-derived amino acid, is widely used as a functional ingredient in foods. Here, we evaluated the in vivo effects of l-theanine on glutamine metabolism in healthy rats and in a stressed rat model, which was established by infecting rats with enterotoxigenic Escherichia coli (E44813). The results showed that l-theanine significantly enhanced the synthesis of glutamine and stabilized the intestinal tract in healthy rats. In E44813-stressed rats, l-theanine could replace l-glutamine, thereby alleviating intestinal stress by reducing the expression of inflammatory factors, enhancing the activities of antioxidant enzymes, and regulating glutamine metabolism by modulating its synthesis. Treatment with a combination of l-theanine and l-glutamine was superior to treatment with l-glutamine alone in enhancing the activity of antioxidant enzymes, reducing the expression of inflammatory factors, and increasing the intestinal villi height and crypt depth.Graphical abstract
Source: Journal of Functional Foods - Category: Nutrition Source Type: research

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Source: Sensing and Bio Sensing Research - Category: Research Source Type: research
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Source: Minerva Urologica e Nefrologica - Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research
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Source: Sensors and Actuators B: Chemical - Category: Chemistry Source Type: research
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