Drug for dilutional hyponatremia

Drug useful in management of dilutional hyponatremia:
a) Tolvaptan
b) Enalapril
c) Omapatrilat
d) Ambrisentan
Correct Answer: a) Tolvaptan
Tolvaptan is a vasopressin antagonist useful in the management of dilutional hyponatremia. It should not be used in hypovolemic hyponatremia. It is orally active and a selective V2 antagonist. Tolvaptan is an aquaretic causing free water excretion without loss of electrolytes.
Schrier RW. Tolvaptan, a Selective Oral Vasopressin V2-Receptor Antagonist, for Hyponatremia. N Engl J Med 2006; 355:2099-2112

Source: Cardiophile MD - July 22, 2013 Category: Cardiology Authors: Prof. Dr. Johnson Francis MD, DM, FACC, FRCP Edin, FRCP London Tags: Cardiology MCQ DM / DNB Cardiology Entrance Source Type: blogs