Allergic Immune Diseases and the Risk of Mortality Among Patients Hospitalized for Acute Infection*
The objective of this study was to test the hypothesis that comorbid type 2 immune diseases confer protection against morbidity and mortality due to acute infection.
Design:
Retrospective cohort study of patients hospitalized with an acute infection between November 2008 and January 2016 using electronic health record data.
Setting:
Single tertiary-care academic medical center.
Patients:
Admissions to the hospital through the emergency department with likely infection at the time of admission who may or may not have had a type 2 immune-mediated disease, defined as asthma, allergic rhinitis, atopic dermatitis, or food allergy, as determined by International Classification of Diseases, 9th Revision, Clinical Modification codes.
Interventions:
None.
Measurements and Main Results:
Of 10,789 admissions for infection, 2,578 (24%) had a type 2 disease; these patients were more likely to be female, black, and younger than patients without type 2 diseases. In unadjusted analyses, type 2 patients had decreased odds of dying during the hospitalization (0.47; 95% CI, 0.38–0.59, p
Source: Critical Care Medicine - Category: Emergency Medicine Tags: Clinical Investigations Source Type: research
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