Allergic Immune Diseases and the Risk of Mortality Among Patients Hospitalized for Acute Infection*
The objective of this study was to test the hypothesis that comorbid type 2 immune diseases confer protection against morbidity and mortality due to acute infection. Design: Retrospective cohort study of patients hospitalized with an acute infection between November 2008 and January 2016 using electronic health record data. Setting: Single tertiary-care academic medical center. Patients: Admissions to the hospital through the emergency department with likely infection at the time of admission who may or may not have had a type 2 immune-mediated disease, defined as asthma, allergic rhinitis, atopic dermatitis, or food allergy, as determined by International Classification of Diseases, 9th Revision, Clinical Modification codes. Interventions: None. Measurements and Main Results: Of 10,789 admissions for infection, 2,578 (24%) had a type 2 disease; these patients were more likely to be female, black, and younger than patients without type 2 diseases. In unadjusted analyses, type 2 patients had decreased odds of dying during the hospitalization (0.47; 95% CI, 0.38–0.59, p
We examined our primary care birth cohort of 158,510 pediatric patients, of whom 214 patients met 2017 FPIES diagnostic criteria. We measured the influence of FPIES on developing subsequent atopic disease.ResultsPediatric FPIES incidence was between 0.17% and 0.42% depending on birth year. As in prior reports, most patients had an acute presentation (78%), and milk, soy, oat, rice, potato, and egg were common triggers. The mean age of diagnosis was 6.8 months. Atopic comorbidity was higher in patients with FPIES compared with healthy children (AD, 20.6% vs 11.7%; IgE-FA, 23.8% vs 4.0%; asthma, 26.6% vs 18.4%; AR, 28.0% vs 16.7%; P
Allergic diseases such as atopic dermatitis (AD), food allergy (FA), asthma and allergic rhinitis (AR) are common; according to a national birth cohort study in Japan, almost half of pregnant women reported a history of allergic disease.1 Given that genetic factors, including family history, are predictors of allergic diseases in offspring, we expect the birth of many infants who carry a high risk of developing allergies. Among allergy prevention strategies, the effectiveness of primary prevention of eczema in high-risk infants by the topical application of emollient during the neonatal period has been demonstrated in two ...
We examined our primary care birth cohort of 158,510 pediatric patients, of which 214 patients met 2017 FPIES diagnostic criteria. We measured the influence of FPIES on developing subsequent atopic disease.ResultsPediatric FPIES incidence was between 0.17% and 0.42% depending on birth year. As in prior reports, most patients had an acute presentation (78%) and milk, soy, oat, rice, potato, and egg were common triggers. The mean age of diagnosis was 6.8 months. Atopic comorbidity was higher in FPIES patients compared to healthy children (AD, 20.6% vs. 11.7%; IgE-FA, 23.8% vs. 4.0%; asthma, 26.6% vs. 18.4%; AR, 28.0% vs. 16.7%; p
Conclusions: Thus, dermato-respiratory syndrome as a manifestation of food allergy in children characterized by polyvalent sensitization to food allergens with a predominance of sensitization to ovalbumin, casein and gliadin.
Objective: to evaluate the clinical efficacy and safety of long-term anti-IgE therapy patients with severe uncontrolled asthma.Materials and Methods: in Chelyabinsk city from November 2016 35 patients regularly receive omalizumab therapy - 9 men (26%) and 26 women (74%), the average age 44.5±14.1 years, the duration of asthma - 25.2±11.5 years. All patients had allergic pathology: allergic rhinitis - 100%, pollinosis - 79.4%, food allergy - 44.1%, atopic dermatitis - 26.5%. The level of total IgE in the blood is from 72 to 787 IU/ml, high sesitization to household (88.6%), epidermal (62.9%), pollen (74.3%) al...
Patient is a 9-year-old male with a history of moderate/severe atopic dermatitis, allergic rhinitis and eosinophilic esophagitis (EoE). He initially presented to an outside gastroenterologist at 3 years of age due to poor growth and picky eating. He had an endoscopy performed, which demonstrated esophageal eosinophilia. At the time of EoE diagnosis, patient was without IgE mediated food allergies, specifically tolerating dairy products regularly without symptoms. His initial management of eosinophilic esophagitis included the 4-food elimination diet.
Despite being classified as an allergy, the epidemiologic relationships between food protein-induced enterocolitis syndrome (FPIES) and other allergic manifestations (atopic dermatitis, AD; IgE-mediated food allergy, IgE-FA; asthma; allergic rhinitis, AR) are not well understood.
Atopic dermatitis (AD) is a chronic, relapsing disease that typically manifests in childhood and improves with age. Studies have demonstrated that the presence of AD increases the risk of developing food allergy, allergic rhinitis, and asthma later in life. Although children with AD are more likely to produce allergen-specific immunoglobulin E, there is conflicting evidence that allergen avoidance improves disease severity. Furthermore, food-elimination diets in patients with AD may increase the risk of developing immediate, life-threatening reactions to the removed food. The most effective treatments of AD aim to repair a...
To evaluate the role of atopy (i.e. atopic dermatitis, allergic rhinitis, asthma, and food allergies) and its consequences on developing meatal stenosis in boys.
Conclusions: Children with IBD should be constantly monitored by medical professionals, not only due to the underlying disease but also due to a possible concomitant allergic disease. PMID: 31333345 [PubMed]