Elevated serum levels of interleukin-37 correlate with poor prognosis in gastric cancer.

Elevated serum levels of interleukin-37 correlate with poor prognosis in gastric cancer. Rev Esp Enferm Dig. 2019 Nov 13;111: Authors: Zhang Y, Tang M, Wang XG, Gu JH, Zhou LN, Jin J, Li P, Wang LQ, Chen MB Abstract BACKGROUND: interleukin-37 (IL-37) is as a natural suppressor of the innate inflammatory and immune responses. It has also been reported to be involved in carcinogenesis and metastasis. The present case-control study was designed to investigate the role of serum levels of IL-37 in patients with gastric cancer. METHODS: serum IL-37 levels were determined using the enzyme-linked immunosorbent assay in 180 patients diagnosed with gastric cancer and 100 healthy controls. The association between IL-37 levels and clinical factors was assessed. Univariate and multivariate analyses were performed to investigate the prognostic significance of these parameters in gastric cancer. RESULTS: serum IL-37 levels in gastric cancer patients (5.606 ± 0.837 pg/ml) were significantly higher than those in healthy controls (2.364 ± 0.210 pg/ml, p
Source: Revista Espanola de Enfermedades Digestivas - Category: Gastroenterology Tags: Rev Esp Enferm Dig Source Type: research

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Authors: Galizia G, Auricchio A, de Vita F, Cardella F, Mabilia A, Basile N, Orditura M, Lieto E Abstract PURPOSE: Oncological outcome depends not only on tumor behaviour but also on nutritional and immune-inflammatory host status. Data in gastric cancer are limited. The main aim of this study was to prospectively assess Naples prognostic score (NPS) in gastric cancer patients. NPS was also compared with prognostic nutritional index (PNI), controlling nutritional status (CONUT) score and systemic inflammation score (SIS). METHODS: Overall survival (OS) and complication rates of 415 patients undergoing gastric c...
Source: Annali Italiani di Chirurgia - Category: Surgery Tags: Ann Ital Chir Source Type: research
Publication date: Available online 9 December 2019Source: European Journal of Integrative MedicineAuthor(s): Xiao-Qing Wang, Pei-Bei Duan, Man Zheng, Qian Xu, Li-Hua Yang, A-Qin WangAbstractIntroductionAuricular acupuncture has been used for pain management. A more recent technique which buries an intradermal needle into the skin may provides long lasting stimulation and enhance analgesia. The purpose of this study was to evaluate the efficacy and feasibility of perioperative auricular acupuncture technique via intradermal needling buried on postoperative movement-evoked pain reduction of patients with advanced gastric can...
Source: European Journal of Integrative Medicine - Category: Complementary Medicine Source Type: research
(American Gastroenterological Association) This guideline will aid health care provider decision-making for patients who are undergoing upper endoscopy in North America
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
This study was aimed to investigate the mechanis...
Source: Journal of Experimental and Clinical Cancer Research - Category: Cancer & Oncology Authors: Tags: Research Source Type: research
Conclusion.Detection of CDK12‐LOF genomic alterations and their association with FTDs in a diverse spectrum of malignancies suggests that immunotherapy approaches targeting FINAs derived from CDK12‐associated FTDs may be a broadly applicable strategy that could be explored across cancer types in a tumor‐agnostic manner.Implications for Practice.CDK12 inactivation in ovarian and prostate cancer results in the generation of focal tandem duplications, which can cause fusion‐induced neoantigens. In prostate cancer, CDK12 alterations have demonstrated promise as a potential predictive biomarker for response to immune ch...
Source: The Oncologist - Category: Cancer & Oncology Authors: Tags: Cancer Diagnostics and Molecular Pathology Source Type: research
Cancers, Vol. 11, Pages 1987: Phase 1 Dose Escalation Study of the Allosteric AKT Inhibitor BAY 1125976 in Advanced Solid Cancer—Lack of Association between Activating AKT Mutation and AKT Inhibition-Derived Efficacy Cancers doi: 10.3390/cancers11121987 Authors: Andreas Schneeweiss Dagmar Hess Markus Joerger Andrea Varga Stacy Moulder Apostolia M. Tsimberidou Cynthia Ma Sara A. Hurvitz Christine Rentzsch Marion Rudolph Silke Thiele Oliver Boix Gary Wilkinson Eleni Lagkadinou Matthias Ocker This open-label, phase I first-in-human study (NCT01915576) of BAY 1125976, a highly specific...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
ConclusionLSTG for AUTGC was safe and effective when performed by very experienced surgeons, this technique could be used in patients who needed splenic hilar lymph node dissection.
Source: Surgical Endoscopy - Category: Surgery Source Type: research
AbstractThe oncogenic role ERBB2 amplification is well established in breast and gastric cancers. This has led to the development of a well‐known portfolio of monoclonal antibodies and kinase inhibitors targeting the ERBB2 kinase. More recently, activating mutations in the ERBB2 gene have been increasingly reported in multiple solid cancers and were shown to play an oncogenic role similar to that of ERBB2 amplification. Thus, ERBB2 mutations define a distinct molecular subtype of solid tumors and serve as actionable targets. However, efforts to target ERBB2 mutation has met with limited clinical success, possibly because...
Source: The Oncologist - Category: Cancer & Oncology Authors: Tags: Review, Precision Medicine Clinic: Molecular Tumor Board, Cancer Diagnostics and Molecular Pathology Source Type: research
AbstractBackground.Gastric cancer (GC) is a heterogeneous disease, and substantial efforts have been made to develop a molecular biology‐based classification system for GC. Analysis of the genomic signature is not always feasible, and thus, we aimed to (i) develop and validate a practical immunohistochemistry (IHC)‐ and polymerase chain reaction (PCR)‐based molecular classification of GC and (ii) to assess HER2 status according to this classification.Materials and Methods.A total of 894 consecutive patients with GC from two individual cohorts (training, n = 507; validation, n = 387) were classified using Epstein‐Ba...
Source: The Oncologist - Category: Cancer & Oncology Authors: Tags: Cancer Diagnostics and Molecular Pathology, Gastrointestinal Cancer Source Type: research
BOSTON (CBS) — According to a new study published in the journal Cancer, even light to moderate alcohol intake has been linked to a higher risk of cancer. Researchers at the University of Tokyo and the Harvard T.H. Chan School of Public Health looked at data on over 60,000 cancer patients in Japan. They found drinking as little as one drink a day for 10 years or two drinks a year for five years, was associated would increase overall cancer risk by five percent, such as cancers of the colon, stomach, breast, prostate, and esophagus. Cancer risk was lowest with no alcohol consumption.
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Boston News Health Healthwatch Seen On WBZ-TV Syndicated Local Cancer Dr. Mallika Marshall Drinking Source Type: news
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